Long-term survival after repetitive lymphadenectomy for nodal recurrence of pancreatic neuroendocrine neoplasms: a report of two cases

Author:

Hane Yuma1ORCID,Tsuchikawa Takahiro1ORCID,Takeuchi Satoshi2,Tanaka Kimitaka1,Nakanishi Yoshitsugu1,Asano Toshimichi1,Noji Takehiro1,Kurashima Yo1,Ebihara Yuma1,Murakami Soichi1,Nakamura Toru1,Okamura Keisuke1,Shichinohe Toshiaki1,Hirano Satoshi1

Affiliation:

1. Department of Gastroenterological Surgery II, Division of Surgery, Hokkaido University Faculty of Medicine, Sapporo 060-8638, Japan

2. Department of Medical Oncology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan

Abstract

Abstract Pancreatic neuroendocrine neoplasms (PNENs) are rare, but their incidence has increased in recent years. Curative surgery is recommended in several global guidelines for resectable PNENs. Lymph node recurrence after R0 resection for PNENs is infrequent, and global guidelines recommend surgical resection for recurrence, if resectable. However, data on the prognosis after surgical resection for nodal recurrence of PNENs are limited. We herein report two cases in which long-term survival was achieved after repetitive lymphadenectomy for nodal recurrence of PNENs. In both cases, the pathological findings for primary PNEN showed well-differentiated neuroendocrine neoplasms and R0 resection was successfully performed. The Ki-67 index increased with each resection in both cases. Both patients showed long-term survival (10 and 14 years, respectively). Repetitive lymphadenectomy for nodal recurrence of PNENs may improve patient prognosis.

Publisher

Oxford University Press (OUP)

Subject

Surgery

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