Black rice bran intake reduces phosphorylated tau levels and enhances insulin signaling in the brain of aged normal mice-Reference-Cited by-同舟云学术

Black rice bran intake reduces phosphorylated tau levels and enhances insulin signaling in the brain of aged normal mice

Published:2022-09-20 Issue:11 Volume:86 Page:1570-1575
ISSN:1347-6947
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Hara Takashi¹,Toyama Hanae²,Ohata Yumi²,Ikeuchi Takeshi³^ORCID,Nakamura Sumiko⁴,Joh Toshio¹,Ohtsubo Ken'ichi⁴^ORCID

Affiliation:

1. Department of Agriculture, Faculty of Agriculture, Niigata University , Niigata , Japan

2. Graduate School of Science and Technology, Niigata University , Niigata , Japan

3. Department of Molecular Genetics, Brain Research Institute, Niigata University , Niigata , Japan

4. Faculty of Applied Life Sciences, Niigata University of Pharmacy and Applied Life Sciences , Niigata , Japan

Abstract

ABSTRACT This study reports that black rice bran (BRB) intake for 50-52 consecutive weeks (∼12 months) reduces tau phosphorylation with a concomitant activation of insulin signaling and subsequent PI3K/AKT pathway in the brain of aged normal mice. BRB holds promise for preventing the formation of neurofibrillary tangles consisting of hyperphosphorylated tau, a pathological hallmark of Alzheimer's disease.

Funder

NARO

Cabinet Office, Government of Japan

Cross-ministerial Strategic Innovation Promotion Program

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

https://academic.oup.com/bbb/advance-article-pdf/doi/10.1093/bbb/zbac125/45968011/zbac125.pdf

Reference48 articles.

1. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action;Aguirre;J Biol Chem,2002

2. Insulin signaling pathway and related molecules; role in neurodegeneration and Alzheimer's diseases;Akhtar;Neurochem Int,2020

3. Vascular risk factors and neurodegeneration in ageing related dementias: Alzheimer's disease and vascular dementia;Akinyemi;Current Alzheimer Research,2013

4. Anthocyanin-loaded PEG-gold nanoparticles enhanced the neuroprotection of anthocyanins in an aβ 1-42 mouse model of Alzheimer's disease;Ali;Mol Neurobiol,2017

5. Aging and caloric restriction research: a biological perspective with translational potential;Balasubramanian;EBioMedicine,2017

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Rice-memolin, a novel peptide derived from rice bran, improves cognitive function after oral administration in mice;Scientific Reports;2023-02-18