Advanced bioengineering of female germ cells to preserve fertility

Author:

Ghorbani Sadegh1,Eyni Hossein2343,Norahan Mohammad Hadi5,Zarrintaj Payam6,Urban Nadine7,Mohammadzadeh Alireza8,Mostafavi Ebrahim910,Sutherland Duncan S1

Affiliation:

1. Interdisciplinary Nanoscience Center (iNANO), Aarhus University , Aarhus , Denmark

2. Cellular and Molecular Research Center , School of Medicine, , Tehran , Iran

3. Iran University of Medical Science , School of Medicine, , Tehran , Iran

4. Department of Anatomical Sciences , School of Medicine, , Tehran , Iran

5. School of Engineering and Sciences, Tecnologico de Monterrey Unviersity , Monterrey, NL , Mexico

6. Department of Biomedical and Pharmaceutical Sciences, University of Montana , Missoula, MT , USA

7. Freiburg Centre for Interactive Materials and Bioinspired Technology, University of Freiburg , Freiburg , Germany

8. Department of Bioengineering, Universit y of Pittsburgh , Pittsburgh, PA , USA

9. Stanford Cardiovascular Institute, Stanford University School of Medicine , Stanford, CA , USA

10. Department of Medicine, Stanford University School of Medicine , Stanford, CA , USA

Abstract

Abstract Oogenesis and folliculogenesis are considered as complex and species-specific cellular differentiation processes, which depend on the in vivo ovarian follicular environment and endocrine cues. Considerable efforts have been devoted to driving the differentiation of female primordial germ cells toward mature oocytes outside of the body. The recent experimental attempts have laid stress on offering a suitable microenvironment to assist the in vitro folliculogenesis and oogenesis. Despite developing a variety of bioengineering techniques and generating functional mature gametes through in vitro oogenesis in earlier studies, we still lack knowledge of appropriate microenvironment conditions for building biomimetic culture systems for female fertility preservation. Therefore, this review paper can provide a source for a large body of scientists developing cutting-edge in vitro culture systems for female germ cells or setting up the next generation of reproductive medicine as feasible options for female infertility treatment. The focal point of this review outlines advanced bioengineering technologies such as 3D biofabricated hydrogels/scaffolds and microfluidic systems utilized with female germlines for fertility preservation through in vitro folliculogenesis and oogenesis.

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,General Medicine,Reproductive Medicine

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