A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair

Author:

Bharti Sanjay Kumar1,Sommers Joshua A1,Awate Sanket1,Bellani Marina A1,Khan Irfan1,Bradley Lynda2,King Graeme A2,Seol Yeonee2,Vidhyasagar Venkatasubramanian3,Wu Yuliang3,Abe Takuye4,Kobayashi Koji4,Shin-ya Kazuo5,Kitao Hiroyuki6,Wold Marc S7,Branzei Dana4,Neuman Keir C2ORCID,Brosh Robert M1

Affiliation:

1. Laboratory of Molecular Gerontology, National Institute on Aging, NIH, NIH Biomedical Research Center, 251 Bayview Blvd, Baltimore, MD 21224, USA

2. Laboratory of Single Molecule Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA

3. Department of Biochemistry, University of Saskatchewan, Health Sciences Building, 107 Wiggins Road, Saskatoon, Saskatchewan S7N 5E5, Canada

4. IFOM, the FIRC Institute for Molecular Oncology Foundation, Milan, Italy

5. Department of Life Science and Biotechnology Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST) 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan

6. Department of Molecular Cancer Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan

7. Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA

Funder

Italian Association for Cancer Research

Publisher

Oxford University Press (OUP)

Subject

Genetics

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