Aggregation-induced emission biomaterials for anti-pathogen medical applications: detecting, imaging and killing

Author:

Zhang Zicong1,Deng Ziwei1,Zhu Lixun1,Zeng Jialin1ORCID,Cai Xu Min2,Qiu Zijie1,Zhao Zheng13ORCID,Tang Ben Zhong14

Affiliation:

1. Clinical Translational Research Center of Aggregation-Induced Emission, The Second Affiliated Hospital, School of Medicine, School of Science and Engineering, Shenzhen Key Laboratory of Functional Aggregate Materials, The Chinese University of Hong Kong , Shenzhen, Guangdong 518172, China

2. Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Rescources, International Innovation Center for Forest Chemicals and Materials, College of Chemical Engineering, Nanjing Forestry University , Nanjing 210037, China

3. HKUST-Shenzhen Research Institute, South Area Hi-Tech Park , Nanshan, Shenzhen, Guangdong Province 518057, China

4. Department of Chemistry, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, The Hong Kong University of Science and Technology , Clear Water Bay , Kowloon, Hong Kong, China

Abstract

AbstractMicrobial pathogens, including bacteria, fungi and viruses, greatly threaten the global public health. For pathogen infections, early diagnosis and precise treatment are essential to cut the mortality rate. The emergence of aggregation-induced emission (AIE) biomaterials provides an effective and promising tool for the theranostics of pathogen infections. In this review, the recent advances about AIE biomaterials for anti-pathogen theranostics are summarized. With the excellent sensitivity and photostability, AIE biomaterials have been widely applied for precise diagnosis of pathogens. Besides, different types of anti-pathogen methods based on AIE biomaterials will be presented in detail, including chemotherapy and phototherapy. Finally, the existing deficiencies and future development of AIE biomaterials for anti-pathogen applications will be discussed.

Funder

NSFC

Shenzhen Key Laboratory of Functional Aggregate Materials

Publisher

Oxford University Press (OUP)

Subject

Biomaterials

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