Lymphoedema is chronic swelling developing as a result of failure of the lymphatic system to drain fluid and other substances, such as proteins, from the tissues. This chapter focuses on oedema associated with advanced cancer and other diseases, encountered towards the end of life. It is often of multifactorial origin. Management involves an assessment of contributory factors, consideration of which may be reversible, and treatment, which takes into account the patient’s priorities and the balance of benefit versus burden. Modifications of the combined physical treatments used for chronic lymphoedema are often required in this setting.