Breast Cancer Circulating Tumor Cells: Current Clinical Applications and Future Prospects

Author:

Cani Andi K12,Hayes Daniel F12

Affiliation:

1. Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan Medical School , Ann Arbor, MI , United States

2. Rogel Cancer Center, University of Michigan , Ann Arbor, MI , United States

Abstract

Abstract Background Identification and characterization of circulating tumor markers, designated as “liquid biopsies,” have greatly impacted the care of cancer patients. Although more recently referring to circulating tumor DNA (ctDNA), the term liquid biopsy initially was coined to refer to any blood-borne biomarker related to malignancy, including circulating tumor cells (CTCs) in blood. In this manuscript, we review the specific state of the art of CTCs in breast cancer. Content Liquid biopsies might play a clinical role across the entire spectrum of breast cancer, from risk assessment, prevention, screening, and treatment. CTC counts have been shown to carry clear, independent prognostic information in the latter situation. However, the clinical utility of CTCs in breast cancer remains to be determined. Nonetheless, in addition to CTC enumeration, analyses of CTCs provide tumor molecular information representing the entire, often-heterogeneous disease, relatively noninvasively and longitudinally. Technological advances have allowed the interrogation of CTC-derived information, providing renewed hope for a clinical role in disease monitoring and precision oncology. Summary This narrative review examines CTCs, their clinical validity, and current prospects of clinical utility in breast cancer with the goal of improving patient outcomes.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry (medical),Clinical Biochemistry

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Cancer: Biology and Diagnostics;Clinical Chemistry;2024-01

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