Systematic symptom management in the IMPACT Consortium: rationale and design for 3 effectiveness-implementation trials

Author:

Smith Ashley Wilder1ORCID,DiMartino Lisa23,Garcia Sofia F4,Mitchell Sandra A1ORCID,Ruddy Kathryn J5,Smith Justin D6,Wong Sandra L7,Cahue September8,Cella David4,Jensen Roxanne E1ORCID,Hassett Michael J9,Hodgdon Christine10,Kroner Barbara3,Osarogiagbon Raymond U11ORCID,Popovic Jennifer12,Richardson Kimberly13,Schrag Deborah14,Cheville Andrea L15ORCID,Cella David,Cheville Andrea,Hassett Michael J,Osarogiagbon Raymond U,Schrag Deborah,Wong Sandra L,Kroner Barbara L,Smith Ashley Wilder,DiMartino Lisa,Garcia Sofia,Griffin Joan,Jensen Roxanne,Mitchell Sandra,Ruddy Kathryn,Smith Justin D,Yanez Betina,Bian Jessica J,Dizon Don S,Hazard-Jenkins Hannah W,Ardini Mary-Anne,Ahrens Paige,Austin Jessica,Barrett Fiona,Bass Michael,Begnoche Megan,Cahue September,Caron Kimberly,Chlan Linda,Coughlin Ava,Cronin Christine,Dias Samira,Farisiv Nicolas,Flores Anne Marie,Garcia Martha,Hemming Karla,Herrin Jeph,Hodgdon Christine,Kircher Sheetal,Kroenke Kurt,Lam Veronica,Lancki Nicola,Mai Quan H,Mallow Jennifer,McCleary Nadine J,Norton Wynne,O'Connor Mary,Pachman Deirdre,Pearsonil Loretta,Penedo Frank,Podratz Jewel,Popovic Jennifer,Preiss Liliana,Rahman Parvez,Redmond Sarah,Reich James,Richardson Joshua,Richardson Kimberly,Ridgeway Jennifer,Rutten Lila,Schaepe Karen,Scholtens Denise,Poirier-Shelton Tiana,Silberman Philip,Simpson Jaclyn,Tasker Laura,Tesch Nathan,Tofthagen Cindy,Tramontano Angela,Tyndall Benjamin D,Uno Hajime,Wehbe Firas,Weiner Bryan,

Affiliation:

1. Outcomes Research Branch, Healthcare Delivery Research Program, National Cancer Institute , Bethesda, MD, USA

2. Peter O’Donnell Jr. School of Public Health, University of Texas Southwestern Medical Center , Austin, TX, USA

3. RTI International , Washington, DC, USA

4. Department of Medical Social Sciences and the Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine , Chicago, IL, USA

5. Department of Oncology, Mayo Clinic , Rochester, MN, USA

6. Division of Health Systems Innovation and Research, Department of Population Health Sciences, Spencer Fox Eccles School of Medicine at the University of Utah , Salt Lake City, UT, USA

7. Department of Surgery, Dartmouth-Hitchcock Medical Center , Lebanon, NH, USA

8. American Academy of Allergy, Asthma and Immunology , Chicago, IL, USA

9. Department of Medical Oncology, Dana-Farber Cancer Institute , Boston, MA, USA

10. Guiding Researchers and Advocates to Scientific Partnerships , Baltimore, MD, USA

11. Multidisciplinary Thoracic Oncology Program, Baptist Cancer Center , Memphis, TN, USA

12. Value Evidence and Outcomes, GSK , Waltham, MA, USA

13. Black Cancer Collaborative , Chicago, IL, USA

14. Department of Medical Oncology, Memorial Sloan Kettering Cancer Center , New York, NY, USA

15. Department of Physical Medicine and Rehabilitation, Mayo Clinic , Rochester, MN, USA

Abstract

AbstractCancer and its treatment produce deleterious symptoms across the phases of care. Poorly controlled symptoms negatively affect quality of life and result in increased health-care needs and hospitalization. The Improving the Management of symPtoms during And following Cancer Treatment (IMPACT) Consortium was created to develop 3 large-scale, systematic symptom management systems, deployed through electronic health record platforms, and to test them in pragmatic, randomized, hybrid effectiveness and implementation trials. Here, we describe the IMPACT Consortium’s conceptual framework, its organizational components, and plans for evaluation. The study designs and lessons learned are highlighted in the context of disruptions related to the COVID-19 pandemic.

Funder

National Institutes of Health

Mayo Clinic

Northwestern University

Baptist Health System

Dana-Farber Cancer Institute

Dartmouth-Hitchcock Medical Center

Lifespan Health System

Maine Medical Center

West Virginia University

RTI International

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Oncology

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