1. Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Headley Way, Oxford, UK
2. William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, London, UK
3. Barts Heart Centre, St Bartholomew’s hospital, Barts Health NHS Trust, West Smithfield, London, UK
4. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Centre for Statistics in Medicine, University of Oxford, Old Road Campus, Oxford, UK
5. Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford, UK
6. Department of Clinical Neurosciences, Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, UK
7. Cardiology and Radiology, University of Virginia Health System, Charlottesville, VA, USA