Affiliation:
1. Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China
2. Institute for Metabolic Disease, Fengxian Central Hospital, The Third School of Clinical Medicine, Southern Medical University, Shanghai 201499, China
Abstract
Abstract
Metabolic diseases including type 2 diabetes mellitus (T2DM), non-alcoholic fatty liver disease (NAFLD), and metabolic syndrome (MetS) are alarming health burdens around the world, while therapies for these diseases are far from satisfying as their etiologies are not completely clear yet. T2DM, NAFLD, and MetS are all complex and multifactorial metabolic disorders based on the interactions between genetics and environment. Omics studies such as genetics, transcriptomics, epigenetics, proteomics, and metabolomics are all promising approaches in accurately characterizing these diseases. And the most effective treatments for individuals can be achieved via omics pathways, which is the theme of precision medicine. In this review, we summarized the multi-omics studies of T2DM, NAFLD, and MetS in recent years, provided a theoretical basis for their pathogenesis and the effective prevention and treatment, and highlighted the biomarkers and future strategies for precision medicine.
Funder
National Key Research and Development Project of China
National Natural Science Foundation of China
Program of Shanghai Subject Chief Scientist
Shanghai Municipal Education Commission–Gaofeng Clinical Medicine
Three-year Project of Shanghai TCM Development
Publisher
Oxford University Press (OUP)
Subject
Cell Biology,Genetics,Molecular Biology,General Medicine
Cited by
24 articles.
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