Osimertinib versus standard-of-care EGFR-TKI as first-line treatment for EGFRm advanced NSCLC: FLAURA Japanese subset

Author:

Ohe Yuichiro1,Imamura Fumio2,Nogami Naoyuki3,Okamoto Isamu4,Kurata Takayasu5,Kato Terufumi6,Sugawara Shunichi7,Ramalingam Suresh S8,Uchida Hirohiko9,Hodge Rachel10,Vowler Sarah L10,Walding Andrew10,Nakagawa Kazuhiko11

Affiliation:

1. Department of Thoracic Oncology, National Cancer Center Hospital, Chuo-ku, Tokyo, Japan

2. Department of Thoracic Oncology, Osaka International Cancer Institute, Chuo-ku, Osaka, Japan

3. Department of Thoracic Oncology, National Hospital Organization Shikoku Cancer Center, Minamiumemoto-machi, Matsuyama, Japan

4. Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan

5. Department of Thoracic Oncology, Kansai Medical University Hospital, Hirakata, Osaka, Japan

6. Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Kanazawa-ku, Yokohama, Japan

7. Department of Pulmonary Medicine, Sendai Kousei Hospital, Aoba-ku, Sendai, Japan

8. Winship Cancer Institute, Emory University, Atlanta, GA, USA

9. Research and Development, AstraZeneca K.K., Grand Front Osaka Tower B, Kita-ku, Osaka, Japan

10. AstraZeneca, Cambridge, da Vinci Building, Melbourn Science Park, Melbourn, Cambridgeshire, UK

11. Department of Medical Oncology, Kindai University Hospital, Ohno-higashi, Osaka, Japan

Funder

AstraZeneca

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,Radiology Nuclear Medicine and imaging,Oncology,General Medicine

Reference24 articles.

1. Systemic therapy for stage IV non-small-cell lung cancer: American Society of Clinical Oncology Clinical Practice Guideline update;Hanna;J Clin Oncol,2017

2. Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up;Novello;Ann Oncol,2016

3. Gefitinib or erlotinib vs chemotherapy for EGFR mutation-positive lung cancer: individual patient data meta-analysis of overall survival;Lee;J Natl Cancer Inst,2017

4. Acquired resistance to EGFR tyrosine kinase inhibitors in EGFR-mutant lung cancer: distinct natural history of patients with tumors harboring the T790M mutation;Oxnard;Clin Cancer Res,2011

5. Analysis of tumor specimens at the time of acquired resistance to EGFR-TKI therapy in 155 patients with EGFR-mutant lung cancers;Yu;Clin Cancer Res,2013

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