Affiliation:
1. Shandong First Medical University, China
2. University of Sydney, Australia
Abstract
Abstract
In early January 2020, the novel coronavirus (SARS-CoV-2) responsible for a pneumonia outbreak in Wuhan, China, was identified using next-generation sequencing (NGS) and readily available bioinformatics pipelines. In addition to virus discovery, these NGS technologies and bioinformatics resources are currently being employed for ongoing genomic surveillance of SARS-CoV-2 worldwide, tracking its spread, evolution and patterns of variation on a global scale. In this review, we summarize the bioinformatics resources used for the discovery and surveillance of SARS-CoV-2. We also discuss the advantages and disadvantages of these bioinformatics resources and highlight areas where additional technical developments are urgently needed. Solutions to these problems will be beneficial not only to the prevention and control of the current COVID-19 pandemic but also to infectious disease outbreaks of the future.
Funder
Key research and development project of Shandong province
National Major Project for Control and Prevention of Infectious Disease in China
Academic Promotion Programme of Shandong First Medical University
National Key Research and Development Programme of China
Taishan Scholars Programme of Shandong Province
Publisher
Oxford University Press (OUP)
Subject
Molecular Biology,Information Systems
Cited by
40 articles.
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