Medicinal terpenoid UDP-glycosyltransferases in plants: recent advances and research strategies-Reference-Cited by-同舟云学术

Medicinal terpenoid UDP-glycosyltransferases in plants: recent advances and research strategies

Published:2022-12-27 Issue:5 Volume:74 Page:1343-1357
ISSN:0022-0957
Container-title:Journal of Experimental Botany
language:en
Short-container-title:

Author:

Lu Xu¹²³⁴^ORCID,Huang Lijin²^ORCID,Scheller Henrik V³⁵^ORCID,Keasling Jay D¹³⁴⁶⁷^ORCID

Affiliation:

1. Department of Chemical & Biomolecular Engineering, University of California, Berkeley , CA 94720 , USA

2. State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University , Nanjing 210009 , China

3. Joint BioEnergy Institute, Lawrence Berkeley National Laboratory , Emeryville, CA 94608 , USA

4. Department of Bioengineering, University of California , Berkeley, CA 94720 , USA

5. Department of Plant and Microbial Biology, University of California , Berkeley, CA 94720 , USA

6. Center for Biosustainability, Technical University of Denmark , DK-2800 Kongens Lyngby , Denmark

7. Center for Synthetic Biochemistry, Institute for Synthetic Biology, Shenzhen Institutes for Advanced Technologies , Shenzhen , China

Abstract

Abstract Terpenoid glycosides have significant curative effects on many kinds of diseases. Most of these compounds are derived from medicinal plants. Glycosylation is a key step in the biosynthesis of medicinal terpenoids. In plants, UDP-dependent glycosyltransferases comprise a large family of enzymes that catalyze the transfer of sugars from donor to acceptor to form various bioactive glycosides. In recent years, numerous terpenoid UDP-glycosyltransferases (UGTs) have been cloned and characterized in medicinal plants. We review the typical characteristics and evolution of terpenoid-related UGTs in plants and summarize the advances and research strategies of terpenoid UGTs in medicinal plants over the past 20 years. We provide a reference for the study of glycosylation of terpenoid skeletons and the biosynthetic pathways for medicinal terpenoids in plants.

Funder

National Natural Science Foundation of China

Publisher

Oxford University Press (OUP)

Subject

Plant Science,Physiology

Link

https://academic.oup.com/jxb/advance-article-pdf/doi/10.1093/jxb/erac505/49199100/erac505.pdf

Reference144 articles.

1. Genomics-based selection and functional characterization of triterpene glycosyltransferases from the model legume Medicago truncatula;Achnine;The Plant Journal,2005

2. Structure-based enzyme engineering improves donor–substrate recognition of Arabidopsis thaliana glycosyltransferases;Akere;The Biochemical Journal,2020

3. Structure–function relationships of membrane-associated GT-B glycosyltransferases;Albesa-Jové;Glycobiology,2014

4. UDP-glycosyltransferases from the UGT73C subfamily in Barbarea vulgaris catalyze sapogenin 3-O-glucosylation in saponin-mediated insect resistance;Augustin;Plant Physiology,2012

5. Biosynthesis, evolution and ecology of microbial terpenoids;Avalos;Natural Product Reports,2022

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Plant secondary metabolite and glycosyltransferases;Proceedings of the Institute of Biology;2023-12-31

2. Metabolite and transcriptomic changes reveal the ripening process in Sinopodophyllum hexandrum fruit;Industrial Crops and Products;2023-12