Genomic analyses in African populations identify novel risk loci for cleft palate

Author:

Butali Azeez1,Mossey Peter A2,Adeyemo Wasiu L3,Eshete Mekonen A4,Gowans Lord J J5,Busch Tamara D1,Jain Deepti6,Yu Wenjie7,Huan Liu8,Laurie Cecelia A6,Laurie Cathy C6,Nelson Sarah6ORCID,Li Mary1,Sanchez-Lara Pedro A9,Magee William P10,Magee Kathleen S11,Auslander Allyn10,Brindopke Frederick10,Kay Denise M12,Caggana Michele12,Romitti Paul A13,Mills James L14,Audu Rosemary15,Onwuamah Chika15,Oseni Ganiyu O16,Owais Arwa17,James Olutayo3,Olaitan Peter B16,Aregbesola Babatunde S18,Braimah Ramat O19,Oginni Fadekemi O18,Oladele Ayodeji O18,Bello Saidu A20,Rhodes Jennifer21,Shiang Rita21,Donkor Peter5,Obiri-Yeboah Solomon5,Arthur Fareed Kow Nanse5,Twumasi Peter5,Agbenorku Pius5,Plange-Rhule Gyikua5,Oti Alexander Acheampong5,Ogunlewe Olugbenga M3,Oladega Afisu A3,Adekunle Adegbayi A3,Erinoso Akinwunmi O3,Adamson Olatunbosun O3,Elufowoju Abosede A3,Ayelomi Oluwanifemi I3,Hailu Taiye4,Hailu Abiye4,Demissie Yohannes4,Derebew Miliard4,Eliason Steve7,Romero-Bustillous Miguel7,Lo Cynthia1,Park James1,Desai Shaan1,Mohammed Muiawa1,Abate Firke4,Abdur-Rahman Lukman O22,Anand Deepti23,Saadi Irfaan24ORCID,Oladugba Abimibola V25,Lachke Salil A23,Amendt Brad A7,Rotimi Charles N26,Marazita Mary L27,Cornell Robert A7,Murray Jeffrey C28,Adeyemo Adebowale A26

Affiliation:

1. Department of Oral Pathology, Radiology and Medicine, College of Dentistry, University of Iowa, Iowa, IA, USA

2. Department of Orthodontics, University of Dundee, Dundee, UK

3. Department of Oral and Maxillofacial Surgery, University of Lagos, Akoka, Lagos, Nigeria

4. School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia

5. Kwame Nkrumah University of Science and Technology, Kumasi, Ashanti, Ghana

6. Department of Biostatistics, Genetic Analysis Center, University of Washington, Seattle, WA, USA

7. Department of Anatomy and Cell Biology, University of Iowa, Iowa, IA, USA

8. State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST, Ministry of Science and Technology) and Key Laboratory for Oral Biomedicine of Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China

9. Department of Pediatrics, Cedars-Sinai Medical Center, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA, USA

10. Division of Plastic and Maxillofacial Surgery, Children's Hospital Los Angeles, Los Angeles, CA, USA

11. Operation Smile, 3641 Faculty Boulevard, Virginia Beach, VA, USA

12. Wadsworth Center, New York State Department of Health, Albany, NY, USA

13. Department of Epidemiology, College of Public Health, University of Iowa, Iowa, IA, USA

14. Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, MD, USA

15. Department of Virology, Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria

16. Department of Plastic Surgery, Ladoke Akintola University of Science and Technology, Osogbo, Oyo, Nigeria

17. Department of Pediatric Dentistry, University of Iowa, Iowa, IA, USA

18. Department of Oral and Maxillofacial Surgery, Obafemi Awolowo University, Ile-Ife, Osun, Nigeria

19. Department of Oral and Maxillofacial Surgery, Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria

20. State House Clinic, Asokoro, Abuja, Nigeria

21. Virginia Commonwealth University School of Medicine, Richmond, VA, USA

22. Division of Pediatric Surgery, Department of Surgery, University of Ilorin, Ilorin, Kwara, Nigeria

23. Center for Bioinformatics and Computational Biology, University of Delaware, Newark, DE, USA

24. Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas, KS, USA

25. Department of Biostatistics, University of Nigeria, Nssuka, Enugu, Nigeria

26. Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, MD, USA

27. Center for Craniofacial and Dental Genetics, Department of Oral Biology, School of Dental Medicine; Department of Human Genetics, Graduate School of Public Health, and Clinical and Translational Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA

28. Department of Pediatrics, University of Iowa, Iowa, IA, USA

Funder

National Institute of Dental and Craniofacial Research

Robert Wood Johnson Foundation

National Institutes of Health

Ghana Cleft Foundation

Intramural Research Program of the National Institutes of Health in the CRGGH

Intramural Research Program of the National Institutes of Health

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

Oxford University Press (OUP)

Subject

Genetics(clinical),Genetics,Molecular Biology,General Medicine

Reference67 articles.

1. Cleft lip and palate;Mossey;Lancet,2009

2. Africa has unique and urgent barriers to cleft care: lessons from practitioners at the Pan-African Congress on cleft lip and palate;Adetayo;Pan Afr. Med. J.,2012

3. Quality of life of family caregivers of children with orofacial clefts in Nigeria: a mixed-methods study;Awoyale;Oral Dis.,2015

4. Cleft lip and palate: understanding genetic and environmental influences;Dixon;Nat. Rev. Genet.,2011

5. Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24;Birnbaum;Nat. Genet.,2011

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