1. Department of Cardiology, Newham University Hospital, Barts Health NHS Trust , Glen Road, London E13 8SL , UK
2. Department of Cardiology, Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust , West Smithfield, London EC1A 7BE , UK
3. NIHR Barts Biomedical Research Centre, William Harvey Research Institute, Queen Mary University of London , Charterhouse Square, London EC1M 6BQ , UK
4. Leeds Teaching Hospitals NHS Trust Department of Orthopaedics, , Leeds LS9 7TF , UK
5. Department of Medicine and Medical Education, Leighton Hospital, Mid Cheshire Hospitals NHS Foundation Trust , Cheshire CW1 4QJ , UK
6. Department of Primary Care and Public Health, Imperial College London , London SW7 5NH , UK