1. Institute for Systems Medicine and Faculty of Human Medicine, MSH Medical School Hamburg , Am Kaiserkai 1, Hamburg 20457 , Germany
2. Institute for Theoretical Biology (ITB), Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health , Philippstraße 13, Berlin 10117 , Germany