1. Department of Internal Medicine, S.C. Medicina Generale 1, Medical Center, Ospedale di Circolo e Fondazione Macchi, ASST Sette Laghi , Varese , Italy
2. Division of Cardiovascular Medicine, Department of Medicine, Robert M. Berne Cardiovascular Research Center, University of Virginia , 415 Lane Rd (MR5), PO Box 801394, Charlottesville, VA 22903 , USA