Affiliation:
1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Macau , China
2. State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine , Guangzhou, 51080 , China
3. Guangdong-Hong Kong-Macau Joint Lab on Chinese Medicine and Immune Disease Research , Guangzhou, 510080 , China
Abstract
AbstractAutophagy is a highly conserved bulk degradation mechanism that degrades damaged organelles, aged proteins and intracellular contents to maintain the homeostasis of the intracellular microenvironment. Activation of autophagy can be observed during myocardial injury, during which inflammatory responses are strongly triggered. Autophagy can inhibit the inflammatory response and regulate the inflammatory microenvironment by removing invading pathogens and damaged mitochondria. In addition, autophagy may enhance the clearance of apoptotic and necrotic cells to promote the repair of damaged tissue. In this paper, we briefly review the role of autophagy in different cell types in the inflammatory microenvironment of myocardial injury and discuss the molecular mechanism of autophagy in regulating the inflammatory response in a series of myocardial injury conditions, including myocardial ischemia, ischemia/reperfusion injury and sepsis cardiomyopathy.
Funder
National Natural Science Foundation of China
Shenzhen Fundamental Research Program
Science and Technology Development Fund
University of Macau
Macao Youth Scholars Program
Guangdong Basic and Applied Basic Research Foundation
Science and Technology Foundation of Guangzhou City
State Key Laboratory of Dampness Syndrome of Chinese Medicine Research Foundation
Scientific Research Projects of Guangdong Bureau of Traditional Chinese Medicine
TCM Research Fund of Guangdong Provincial Hospital of Chinese Medicine
Guangdong-Hong Kong-Macau Joint Lab
Publisher
Oxford University Press (OUP)
Subject
Critical Care and Intensive Care Medicine,Dermatology,Biomedical Engineering,Emergency Medicine,Immunology and Allergy,Surgery
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