High Prevalence of Unconfirmed Positive Human Immunodeficiency Virus (HIV) Polymerase Chain Reaction Test Results Among African Infants With HIV Exposure in the International Epidemiology Databases to Evaluate AIDS Consortium-Reference-Cited by-同舟云学术

High Prevalence of Unconfirmed Positive Human Immunodeficiency Virus (HIV) Polymerase Chain Reaction Test Results Among African Infants With HIV Exposure in the International Epidemiology Databases to Evaluate AIDS Consortium

Published:2024-05-14 Issue: Volume: Page:
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Carlucci James G¹^ORCID,Huntington Thomas²,Technau Karl-Günter³,Yotebieng Marcel⁴,Leroy Valériane⁵,Anderson Kim⁶,Amorissani-Folquet Madeleine⁷,Wools-Kaloustian Kara⁸,Edmonds Andrew⁹

Affiliation:

1. Department of Pediatrics, Indiana University School of Medicine , Indianapolis, Indiana , USA

2. Indiana University School of Medicine , Indianapolis, Indiana , USA

3. Department of Paediatrics and Child Health, Faculty of Health Sciences, Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, University of the Witwatersrand , Johannesburg , South Africa

4. Department of Medicine, Albert Einstein College of Medicine , New York, New York , USA

5. CERPOP, SPHERE, Inserm, University of Toulouse , Toulouse , France

6. Faculty of Health Sciences, Centre for Infectious Disease Epidemiology and Research, School of Public Health, University of Cape Town , Cape Town , South Africa

7. Department of Pediatrics, University Houphouet-Boigny , Abidjan , Côte d’Ivoire

8. Department of Medicine, Indiana University School of Medicine , Indianapolis, Indiana , USA

9. Department of Epidemiology, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina , USA

Abstract

Abstract In a large, multiregional cohort of African infants with human immunodeficiency virus (HIV) exposure, 44% of those with a positive HIV polymerase chain reaction test lacked a confirmatory positive test. Efforts are needed to ensure high-fidelity implementation of HIV testing algorithms so that all positive results are confirmed.

Funder

Eunice Kennedy Shriver National Institute of Child Health and Human Development

National Institute of Allergy and Infectious Diseases

National Cancer Institute

National Institute of Mental Health

National Institute on Drug Abuse

National Heart, Lung, and Blood Institute

National Institute on Alcohol Abuse and Alcoholism

National Institute of Diabetes and Digestive and Kidney Diseases

Fogarty International Center

Publisher

Oxford University Press (OUP)