The role of IFN-γ-mediated host immune responses in monitoring and the elimination of Toxoplasma gondii infection
Author:
Ihara Fumiaki12,
Yamamoto Masahiro12
Affiliation:
1. Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University , Yamadaoka, Suita, Osaka 565-0871 , Japan
2. Laboratory of Immunoparasitology, WPI Immunology Frontier Research Center, Osaka University , Yamadaoka, Suita, Osaka 565-0871 , Japan
Abstract
Abstract
Toxoplasma gondii is a pathogenic protozoan parasite of the Apicomplexa family that affects approximately 30% of the world’s population. Symptoms are usually mild in immunocompetent hosts, but it can pose significant health risks to immunosuppressed patients and pregnant women. Current treatment options are limited, and new therapies and vaccines are needed. The innate immune system is the first to recognize T. gondii infection and activates pro-inflammatory cytokines and chemokines to promote acquired immunity. The IL-12/IFN-γ axis is particularly important, and when this pathway is inhibited, infection becomes uncontrolled and lethal. In mice, receptors such as Toll-like receptor 11 (TLR11), TLR12, and chemokine receptors are involved in T. gondii recognition and the modulation of immune responses. In humans, where TLR11 and TLR12 are absent, other mechanisms have been reported as the innate immune sensing system in T. gondii infection. Immune cells activated in response to infection produce interleukin (IL)-12, which stimulates the proliferation of natural killer cells and T cells and promotes the production of interferon (IFN)-γ. Several IFN-γ-induced anti-T. gondii defense mechanisms inhibit parasite growth. These include nitric oxide (NO) production, indoleamine 2,3-dioxygenase, and the destruction of parasitophorous vacuoles by IFN-γ-inducible immunity related GTPase groups (IRGs and GBPs). Recent studies focusing on the diversity of IRGs in rodents and effector molecules in T. gondii suggest that host immune mechanisms and pathogen immune evasion mechanisms have co-evolved. Furthermore, it has been suggested that cysts are not simply dormant during chronic infection. This review summarizes recent findings on anti-T. gondii innate, adaptive, and cell-autonomous immune responses.
Funder
Astellas Foundation for Research on Metabolic Disorders
Japan Science and Technology Agency
Ministry of Education, Culture, Sports, Science and Technology
Oita University
Osaka University
Takeda Science Foundation
Publisher
Oxford University Press (OUP)
Subject
Immunology,General Medicine,Immunology and Allergy
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