The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study

Author:

Dahoun Tarik123,Pardiñas Antonio F4,Veronese Mattia5,Bloomfield Michael A P12678,Jauhar Sameer126,Bonoldi Ilaria126,Froudist-Walsh Sean9,Nosarti Chiara610,Korth Carsten11,Hennah William121314ORCID,Walters James4,Prata Diana151617,Howes Oliver D126

Affiliation:

1. Psychiatric Imaging Group, Robert Steiner MRI Unit, MRC London Institute of Medical Sciences, Imperial College London, Hammersmith Hospital, London, UK

2. Faculty of Medicine, Institute of Clinical Sciences (ICS), Imperial College London, Hammersmith Hospital, London, UK

3. Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford OX37 JX, UK

4. Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK

5. Centre for Neuroimaging Sciences, King’s College London, London, UK

6. Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King’s College London, London, UK

7. Division of Psychiatry, University College London, London, UK

8. Clinical Psychopharmacology Unit, Research Department of Clinical, Educational and Health Psychology, University College London, London, UK

9. Center for Neural Science, New York University, New York, NY, USA

10. Division of Imaging Sciences & Biomedical Engineering, Centre for the Developing Brain, King’s College London, London, UK

11. Department Neuropathology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

12. Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland

13. Mental Health Unit, Department of Health, National Institute for Health and Welfare, Helsinki, Finland

14. Medicum, University of Helsinki, Helsinki, Finland

15. Instituto de Biofísica e Engenharia Biomédica, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal

16. Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King’s College London, London, UK

17. Instituto Universitário de Lisboa (ISCTE-IUL), Cis-IUL, Lisbon, Portugal

Funder

EU-FP7 MC-ITN IN-SENS

National Institute for Health Research

Oxford Health NHS Foundation Trust

Medical Research Council (MRC) Centre

NIHR Biomedical Research Centre at South London

Maudsley NHS Foundation Trust

Medical Faculty of the Heinrich Heine University Düsseldorf

March of Dimes Foundation

Medical Research Council

British Medical Association

UCL Hospitals Neurosciences Biomedical Research Centre

Academy of Finland

UK National Institute for Health Research Fellowship

Marie Curie Career Integration

Fundação para Ciência e Tecnologia (FCT) Investigator

Medical Research Council-UK

Maudsley Charity

Brain and Behavior Research Foundation

Wellcome Trust

Biomedical Research Centre at South London

Publisher

Oxford University Press (OUP)

Subject

Genetics(clinical),Genetics,Molecular Biology,General Medicine

Reference100 articles.

1. The dopamine hypothesis of schizophrenia: a review;Meltzer;Schizophr. Bull,1976

2. Glutamate and dopamine in schizophrenia: an update for the 21st century;Howes;J. Psychopharmacol,2015

3. Antipsychotic drug doses and neuroleptic/dopamine receptors;Seeman;Nature,1976

4. Dopamine receptors and average clinical doses;Creese;Science,1976

5. The significance of dopamine-receptor blockade for the mechanism of action of neuroleptic drugs;van Rossum;Arch. Int. Pharmacodyn. Ther,1966

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