Metabolic regulation of NK cell antiviral functions during cytomegalovirus infection

Author:

Cimpean Maria1ORCID,Cooper Megan A1ORCID

Affiliation:

1. Department of Pediatrics, Division of Rheumatology/Immunology, Washington University in St. Louis , 660 S. Euclid Ave, Box 8208, St. Louis, MO 63110 , United States

Abstract

Abstract Natural killer (NK) cells quickly mount cytotoxic responses, produce cytokines, and proliferate in response to infected or transformed cells. Moreover, they can develop memory, with enhanced effector responses following activation, in some cases with antigen specificity. To optimally execute these functions, NK cells undergo metabolic reprogramming. Here, we discuss the interplay between metabolism and NK cell function in the context of viral infections. We review findings supporting metabolic regulation of NK cell effector functions, with a focus on NK cell antiviral infection in the context of cytomegalovirus in the mouse (MCMV) and human (HCMV).

Funder

NIH

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,Immunology,Immunology and Allergy

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