In vitro effect of diazoxon on cell signaling and second messengers in Nile tilapia (Oreochromis niloticus) leukocytes

Author:

Camacho-Pérez Milton Rafael123,Díaz-Resendiz Karina Janice Guadalupe23ORCID,Ortiz-Butrón Rocío4,Covantes-Rosales Carlos Eduardo23,Benitez-Trinidad Alma Betsaida23,Girón-Pérez Daniel Alberto23,Toledo-Ibarra Gladys Alejandra23,Pavón Lenin5,Girón-Pérez Manuel Iván23ORCID

Affiliation:

1. Programa de Maestría en Ciencias Biológico Agropecuarias, Universidad Autónoma de Nayarit , Carretera Tepic-Compostela Km. 9. Xalisco, Nayarit C.P. 63780 , México

2. Laboratorio de Inmunotoxicología, Secretaría de Investigación y Posgrado, Universidad Autónoma de Nayarit , Ciudad de la Cultura S/N, Centro, Tepic, Nayarit C.P. 63000 , México

3. Laboratorio Nacional de Investigación para la Inocuidad Alimentaria (LANIIA)–Unidad Nayarit, Universidad Autónoma de Nayarit , Calle Tres S/N. Colonia, Cd. Industrial, Tepic, Nayarit C.P. 63000 , México

4. Departamento de Fisiología “Mauricio Russek”, Escuela Nacional de Ciencias Biológicas , IPN, Prol. Carpio y Plan de Ayala, S/N, CDMX C.P. 11340 , México

5. Laboratorio de Psicoinmunología, Dirección de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz , Colonia San Lorenzo Huipulco, Calzada México-Xochimilco 101, Tlalpan Ciudad de México C.P. 14370 , México

Abstract

Abstract The physiological and molecular responses of leukocytes are altered by organophosphate pesticides. Some reports have shown that diazinon causes immunotoxic effects; diazoxon, the oxon metabolite of diazinon, is attributed to influence the immune response by affecting the leukocyte cholinergic system. In this study, the in vitro effects of diazoxon on molecules involved in cell signaling (cAMP, IP3, DAG, JAK1, and STAT3), which play a crucial role in the activation, differentiation, and survival of leukocytes, were evaluated. Data indicate that diazoxon leads to a decrease in cAMP concentration and an increase in basal IP3 levels. However, diazoxon does not affect basal levels of JAK1 and STAT3 phosphorylation. Instead, diazoxon inhibits leukocyte responsiveness to phorbol myristate acetate and ionomycin, substances that, under normal conditions, enhance JAK/STAT signaling. These findings demonstrate that diazoxon significantly affects key molecular parameters related to cell signaling.

Funder

CONAHCyT-Mexico

Fortalecimiento de las Capacidades Analíticas y Científicas Del Laboratorio Nacional LANIIA-Nayarit

Maestría en Ciencias Biológico Agropecuarias

Autonomous University of Nayarit

Publisher

Oxford University Press (OUP)

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Diazoxon exposure increases susceptibility to infection by Salmonella Typhimurium;International Journal of Environmental Health Research;2024-06-06

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