Radiomics-based prediction for tumour spread through air spaces in stage I lung adenocarcinoma using machine learning

Author:

Chen Donglai1,She Yunlang1,Wang Tingting2,Xie Huikang3,Li Jian4,Jiang Gening1,Chen Yongbing5,Zhang Lei1,Xie Dong1,Chen Chang1

Affiliation:

1. Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China

2. Department of Radiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China

3. Department of Pathology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China

4. Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi Medical College, Zunyi, China

5. Department of Thoracic Surgery, The Second Affiliated Hospital of Soochow University, Medical College of Soochow University, Suzhou, China

Abstract

Abstract OBJECTIVES As evidence has proven that sublobar resection is oncologically contraindicated by tumour spread through air spaces (STAS), its preoperative recognition is vital in customizing surgical strategies. We aimed to assess the value of radiomics in predicting STAS in stage I lung adenocarcinoma. METHODS We retrospectively reviewed the patients with stage I lung adenocarcinoma, who accepted curative resection in our institution between January 2011 and December 2013. Using ‘PyRadiomics’ package, 88 radiomics features were extracted from computed tomography (CT) images and a prediction model was consequently constructed using Naïve Bayes machine-learning approach. The accuracy of the model was assessed through receiver operating curve analysis, and the performance of the model was validated both internally and externally. RESULTS A total of 233 patients were included as the training cohort with 69 (29.6%) patients being STAS (+). Patients with STAS had worse recurrence-free survival and overall survival (P < 0.001). After feature extraction, 5 most contributing radiomics features were selected out to develop a Naïve Bayes model. In the internal validation, the model exhibited good performance with an area under the curve value of 0.63 (0.55–0.71). External validation was conducted on a test cohort with 112 patients and produced an area under the curve value of 0.69. CONCLUSIONS CT-based radiomics is valuable in preoperatively predicting STAS in stage I lung adenocarcinoma, which may aid surgeons in determining the optimal surgical approach.

Funder

Shanghai Hospital Development Center

National Natural Science Foundation of China

Clinical Research Foundation of Shanghai Pulmonary Hospital

Shanghai Municipal Health Commission

Technology Commission of Shanghai Municipality

Suzhou Key Laboratory of Thoracic Oncology

Suzhou Key Discipline for Medicine

Science and Technology Research Foundation of Suzhou Municipality

Municipal Program of People's Livelihood Science and Technology in Suzhou

Publisher

Oxford University Press (OUP)

Subject

Cardiology and Cardiovascular Medicine,Pulmonary and Respiratory Medicine,General Medicine,Surgery

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