Disentangling the genetics of lean mass

Author:

Karasik David12,Zillikens M Carola34,Hsu Yi-Hsiang156,Aghdassi Ali7,Akesson Kristina89,Amin Najaf10,Barroso Inês111213,Bennett David A14,Bertram Lars15,Bochud Murielle16ORCID,Borecki Ingrid B1718,Broer Linda310,Buchman Aron S14,Byberg Liisa19,Campbell Harry20ORCID,Campos-Obando Natalia3,Cauley Jane A21ORCID,Cawthon Peggy M22,Chambers John C23242526,Chen Zhao27,Cho Nam H28,Choi Hyung Jin293031ORCID,Chou Wen-Chi132ORCID,Cummings Steven R22ORCID,de Groot Lisette C P G M33ORCID,De Jager Phillip L3435,Demuth Ilja3637,Diatchenko Luda3839,Econs Michael J40,Eiriksdottir Gudny41ORCID,Enneman Anke W3,Eriksson Joel42,Eriksson Johan G43444546,Estrada Karol31047,Evans Daniel S22,Feitosa Mary F17,Fu Mao48,Gieger Christian495051,Grallert Harald4950525354,Gudnason Vilmundur4155,Lenore Launer J56,Hayward Caroline57ORCID,Hofman Albert34,Homuth Georg58ORCID,Huffman Kim M59,Husted Lise B60,Illig Thomas4961,Ingelsson Erik62,Ittermann Till63,Jansson John-Olov64,Johnson Toby656616,Biffar Reiner67,Jordan Joanne M68,Jula Antti43ORCID,Karlsson Magnus89,Khaw Kay-Tee69,Kilpeläinen Tuomas O707172ORCID,Klopp Norman4973,Kloth Jacqueline S L3,Koller Daniel L40,Kooner Jaspal S232574,Kraus William E75,Kritchevsky Stephen76,Kutalik Zoltán1666,Kuulasmaa Teemu77,Kuusisto Johanna77,Laakso Markku77,Lahti Jari78ORCID,Lang Thomas79,Langdahl Bente L60,Lerch Markus M7,Lewis Joshua R8081,Lill Christina82,Lind Lars83,Lindgren Cecilia84,Liu Yongmei85,Livshits Gregory8687,Ljunggren Östen83,Loos Ruth J F72888990,Lorentzon Mattias91,Luan Jian'an72,Luben Robert N71,Malkin Ida86,McGuigan Fiona E8ORCID,Medina-Gomez Carolina310ORCID,Meitinger Thomas9293,Melhus Håkan83ORCID,Mellström Dan42,Michaëlsson Karl19,Mitchell Braxton D4894ORCID,Morris Andrew P8495,Mosekilde Leif60,Nethander Maria42,Newman Anne B21,O'Connell Jeffery R48,Oostra Ben A9697,Orwoll Eric S98,Palotie Aarno99100,Peacock Munro40,Perola Markus43101102,Peters Annette4950,Prince Richard L80103,Psaty Bruce M104105,Räikkönen Katri106,Ralston Stuart H107,Ripatti Samuli1089911,Rivadeneira Fernando3410,Robbins John A109ORCID,Rotter Jerome I110,Rudan Igor21,Salomaa Veikko43ORCID,Satterfield Suzanne111,Schipf Sabine63,Shin Chan Soo29,Smith Albert V4155,Smith Shad B112ORCID,Soranzo Nicole11,Spector Timothy D87,Stančáková Alena77,Stefansson Kari55113,Steinhagen-Thiessen Elisabeth36,Stolk Lisette34,Streeten Elizabeth A4894,Styrkarsdottir Unnur113,Swart Karin M A114,Thompson Patricia115,Thomson Cynthia A27,Thorleifsson Gudmar113,Thorsteinsdottir Unnur55113,Tikkanen Emmi9943,Tranah Gregory J22,Uitterlinden André G3410,van Duijn Cornelia M1097,van Schoor Natasja M114,Vandenput Liesbeth42ORCID,Vollenweider Peter116,Völzke Henry63,Wactawski-Wende Jean117,Walker Mark118,J Wareham Nicholas70,Waterworth Dawn119ORCID,Weedon Michael N120,Wichmann H-Erich50121122,Widen Elisabeth99,Williams Frances M K87ORCID,Wilson James F20,Wright Nicole C123ORCID,Yerges-Armstrong Laura M48119,Yu Lei14,Zhang Weihua2325,Zhao Jing Hua70ORCID,Zhou Yanhua124,Nielson Carrie M98,Harris Tamara B56,Demissie Serkalem124,Kiel Douglas P15ORCID,Ohlsson Claes42

Affiliation:

1. Hebrew SeniorLife Institute for Aging Research and Harvard Medical School, Boston, MA

2. Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel

3. Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands

4. Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging, Leiden, The Netherlands

5. Department of Medicine, Harvard Medical School, Boston, MA

6. Molecular and Integrative Physiological Sciences Program, Harvard School of Public Health, Boston, MA

7. Department of Medicine A, University of Greifswald, Greifswald, Germany

8. Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden

9. Department of Orthopedics, Skåne University Hospital, Malmö, Sweden

10. Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands

11. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, United Kingdom

12. NIHR Cambridge Biomedical Research Centre

13. University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom

14. Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL

15. Lübeck Interdisciplinary Platform for Genome Analytics, University of Lübeck, Lübeck, Germany

16. University Institute for Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland

17. Division of Statistical Genomics, Department of Genetics

18. Division of Biostatistics, Washington University School of Medicine, St. Louis, MO

19. Department of Surgical Sciences, Uppsala University, Uppsala, Sweden

20. Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh, United Kingdom

21. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA

22. California Pacific Medical Center Research Institute, San Francisco, CA

23. Cardiology, Ealing Hospital NHS Trust, London, United Kingdom

24. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom

25. Imperial College Healthcare NHS Trust, London, United Kingdom

26. NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London, United Kingdom

27. Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ

28. Department of Preventive Medicine, Ajou University School of Medicine, Youngtong-Gu, Suwon, Korea

29. Department of Internal Medicine

30. Department of Anatomy and Cell Biology, Neuroscience Research Institute, Seoul National University College of Medicine, Seoul, Korea

31. Wide River Institute of Immunology, Seoul National University, Hongcheon, Korea

32. Broad Institute, Cambridge, MA

33. Division of Human Nutrition, Wageningen University, AFSG, Wageningen, The Netherlands

34. Center for Translational and Computational Neuroimmunology, Neurology, Columbia University Medical Center, New York, NY

35. Cell Circuits Program, Broad Institute, Cambridge, MA

36. Charité—Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany

37. Berlin Institute of Health, Berlin, Germany

38. Regional Center for Neurosensory Disorders, School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, NC

39. Alan Edwards Centre for Research on Pain, McGill University, Montreal, Canada

40. Department of Medicine and Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN

41. Icelandic Heart Association Holtasmari, Kopavogur, Iceland

42. Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

43. National Institute for Health and Welfare, Helsinki, Finland

44. Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland

45. Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland

46. Folkhalsan Research Centre, Helsinki, Finland

47. Translational Biology, Biogen, Cambridge, MA

48. Program in Personalized and Genomic Medicine, and Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD

49. Research Unit of Molecular Epidemiology

50. Institute of Epidemiology II

51. Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany

52. CCG Type 2 Diabetes, Helmholtz Zentrum München, Neuherberg, Germany

53. German Center for Diabetes Research, Neuherberg, Germany

54. CCG Nutrigenomics and Type 2 Diabetes, Helmholtz Zentrum München, Neuherberg, Germany

55. University of Iceland, Faculty of Medicine, Reykjavik, Iceland

56. Laboratory of Epidemiology and Population Sciences, Intramural Research Program, NIA, Bethesda, MD

57. MRC Human Genetics Unit, IGMM, University of Edinburgh, Edinburgh, United Kingdom

58. Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany

59. Duke Molecular Physiology Institute and Division of Rheumatology, Department of Medicine, Duke University School of Medicine, Durham, NC

60. Aarhus University Hospital, Endocrinology and Internal Medicine, Aarhus, Denmark

61. Department of Human Genetics, Hannover Medical School, Hanover, Germany

62. Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA

63. Institute for Community Medicine, University of Greifswald, Greifswald, Germany

64. Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

65. Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland

66. Swiss Institute of Bioinformatics, Lausanne, Switzerland

67. Centre of Oral Health, Department of Prosthetic Dentistry, Gerodontology and Biomaterials, University of Greifswald, Greifswald, Germany

68. Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, Chapel Hill, NC

69. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom

70. MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom

71. Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

72. Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY

73. Hannover Unified Biobank, Hannover Medical School, Hannover, Germany

74. Faculty of Medicine, National Heart & Lung Institute, Cardiovascular Science, Hammersmith Campus, Hammersmith Hospital, Imperial College London, United Kingdom

75. Duke Molecular Physiology Institute and Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC

76. Sticht Center for Healthy Aging and Alzheimer's Prevention, Wake Forest School of Medicine, Winston-Salem, NC

77. Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland

78. Helsinki Collegium Advanced Studies, University of Helsinki, Helsinki, Finland

79. Department of Radiology and Biomedical Imaging, and School of Dentistry, UC San Francisco, San Francisco, CA

80. School of Medicine and Pharmacology, University of Western Australia, Perth, Australia

81. Centre for Kidney Research, Children's Hospital at Westmead, School of Public Health, Sydney Medical School, The University of Sydney, Sydney, Australia

82. Institute of Neurogenetics, University of Luebeck, Luebeck, Germany

83. Department. of Medical Sciences, Uppsala University, Uppsala, Sweden

84. Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, United Kingdom

85. Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, NC

86. Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

87. Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Campus, London, United Kingdom

88. The Charles Bronfman Institute of Personalized Medicine

89. Institute of Child Health and Development

90. The Genetics of Obesity and Related Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY

91. Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden

92. Institute of Human Genetics, MRI, Technische Universität München, Munich, Germany

93. Institute of Human Genetics, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany

94. Geriatric Research and Education Clinical Center—Veterans Administration Medical Center, Baltimore, MD

95. Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom

96. Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands

97. Centre for Medical Systems Biology & Netherlands Consortium on Healthy Aging, Leiden, The Netherlands

98. Oregon Health & Science University, Portland, OR

99. Institute for Molecular Medicine Finland, University of Helsinki, Helsinki, Finland

100. Department of Medical Genetics, University of Helsinki and University Central Hospital, Helsinki, Finland

101. University of Helsinki, Institute for Molecular Medicine, Finland and Diabetes and Obesity Research Program, Helsinki, Finland

102. University of Tartu, Estonian Genome Center, Tartu, Estonia

103. Department of Endocrinology and Diabetes, Sir Charles Gardiner Hospital, Perth, Australia

104. Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA

105. Kaiser Permanente Washington Health Research Institute, Seattle, WA

106. Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland

107. Molecular Medicine Centre, MRC Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, United Kingdom

108. Hjelt Institute, University of Helsinki, Helsinki, Finland

109. Department of Medicine, University California at Davis, Sacramento, CA

110. Institute for Translational Genomic and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor UCLA Medical Center, Torrance, CA

111. Department of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN

112. Center for Translational Pain Medicine, Department of Anesthesiology, Duke University, Durham, NC

113. deCODE Genetics, Reykjavik, Iceland

114. Department of Epidemiology and Biostatistics, and the EMGO+ Institute; VU University Medical Center, Amsterdam, The Netherlands

115. Department of Pathology, Stony Brook University, Stony Brook, NY

116. Department of Medicine, Internal Medicine, Lausanne University Hospital and Faculty of Biology and Medicine, Lausanne, Switzerland

117. Department of Epidemiology and Environmental Health, University at Buffalo, SUNY, Buffalo, NY

118. Institute of Cellular Medicine (Diabetes), The Medical School, Newcastle University, Framlington Place, Newcastle upon Tyne, United Kingdom

119. Genetics, GlaxoSmithKline, King of Prussia, PA

120. Genetics of Complex Traits, Royal Devon & Exeter Hospital, University of Exeter Medical School, Exeter, United Kingdom

121. Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-Universität, Neuherberg/Munich, Germany

122. Institute of Medical Statistics and Epidemiology, Technical University, Munich, Germany

123. Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL

124. Department of Biostatistics, Boston University School of Public Health, Boston, MA

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

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