Acute heart failure: mechanisms and pre-clinical models—a Scientific Statement of the ESC Working Group on Myocardial Function-Reference-Cited by-同舟云学术

Acute heart failure: mechanisms and pre-clinical models—a Scientific Statement of the ESC Working Group on Myocardial Function

Published:2023-10 Issue:14 Volume:119 Page:2390-2404
ISSN:0008-6363
Container-title:Cardiovascular Research
language:en
Short-container-title:

Author:

Ciccarelli Michele¹^ORCID,Pires Inês Falcão²,Bauersachs Johann³^ORCID,Bertrand Luc⁴^ORCID,Beauloye Christophe⁴,Dawson Dana⁵^ORCID,Hamdani Nazha⁶⁷^ORCID,Hilfiker-Kleiner Denise⁸,van Laake Linda W⁹,Lezoualc’h Frank¹⁰,Linke Wolfgang A¹¹^ORCID,Lunde Ida G¹²,Rainer Peter P¹³¹⁴,Rispoli Antonella¹,Visco Valeria¹,Carrizzo Albino¹¹⁵,Ferro Matteo Dal¹⁶¹⁷^ORCID,Stolfo Davide¹⁶¹⁸,van der Velden Jolanda¹⁹,Zacchigna Serena¹⁷²⁰,Heymans Stephane²¹^ORCID,Thum Thomas²²²³^ORCID,Tocchetti Carlo Gabriele²⁴

Affiliation:

1. Cardiovascular Research Unit, Department of Medicine and Surgery, University of Salerno , Via Salvador Allende , 84081 Baronissi, Italy

2. UnIC@RISE, Department of Surgery and Physiology, Faculty of Medicine of the University of Porto , Alameda Prof. Hernâni Monteiro , 4200-319 Porto, Portugal

3. Department of Cardiology and Angiology, Hannover Medical School , Carl-Neuberg-Str. 1 , 30625 Hannover, Germany

4. Pole of Cardiovascular Research, Institut de Recherche Expérimentale et Clinique, Université Catholique de Louvain , 1200 Brussels , Belgium

5. Aberdeen Cardiovascular and Diabetes Centre, School of Medicine and Dentistry, University of Aberdeen , Aberdeen , UK

6. Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum , 44801 Bochum , Germany

7. Department of Cardiology, St.Josef-Hospital and Bergmannsheil, Ruhr University Bochum , 44801 Bochum , Germany

8. Department of Cardiology and Angiology, Hannover Medical School , Carl-Neuberg Str. 1 , 30625 Hannover, Germany

9. Division Heart and Lungs, Department of Cardiology and Regenerative Medicine Center, University Medical Center Utrecht , Heidelberglaan 100 , 3584 CX Utrecht, The Netherlands

10. Institut des Maladies Métaboliques et Cardiovasculaires, Inserm, Université Paul Sabatier, UMR 1297-I2MC , Toulouse , France

11. Institute of Physiology II, University Hospital Münster , Robert-Koch-Str. 27B , Münster 48149, Germany

12. Division of Diagnostics and Technology (DDT), Akershus University Hospital, and KG Jebsen Center for Cardiac Biomarkers, University of Oslo , Oslo , Norway

13. Division of Cardiology, Department of Internal Medicine, Medical University of Graz , 8036 Graz , Austria

14. BioTechMed Graz - University of Graz , 8036 Graz , Austria

15. Laboratory of Vascular Physiopathology-I.R.C.C.S. Neuromed , 86077 Pozzilli , Italy

16. Cardiothoracovascular Department, Azienda Sanitaria-Universitaria Giuliano Isontina (ASUGI) , Trieste , Italy

17. Laboratory of Cardiovascular Biology, The International Centre for Genetic Engineering and Biotechnology , Trieste , Italy

18. Division of Cardiology, Department of Medicine, Karolinska Institutet , Stockholm , Sweden

19. Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC , Amsterdam , Netherlands

20. Department of Medicine, Surgery and Health Sciences, University of Trieste , Trieste , Italy

21. Department of Cardiology, CARIM School for Cardiovascular Diseases, Maastricht University Medical Centre , Maastricht , The Netherlands

22. Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School , Hannover , Germany

23. Fraunhofer Institute for Toxicology and Experimental medicine , Hannover , Germany

24. Cardio-Oncology Unit, Department of Translational Medical Sciences (DISMET), Center for Basic and Clinical Immunology Research (CISI), Interdepartmental Center of Clinical and Translational Sciences (CIRCET), Interdepartmental Hypertension Research Center (CIRIAPA), Federico II University , Via Pansini 5 , 80131 Naples, Italy

Abstract

Abstract While chronic heart failure (CHF) treatment has considerably improved patient prognosis and survival, the therapeutic management of acute heart failure (AHF) has remained virtually unchanged in the last decades. This is partly due to the scarcity of pre-clinical models for the pathophysiological assessment and, consequently, the limited knowledge of molecular mechanisms involved in the different AHF phenotypes. This scientific statement outlines the different trajectories from acute to CHF originating from the interaction between aetiology, genetic and environmental factors, and comorbidities. Furthermore, we discuss the potential molecular targets capable of unveiling new therapeutic perspectives to improve the outcome of the acute phase and counteracting the evolution towards CHF.

Funder

University Funds for basic research

Fundamental Research of excellence in Strategic

Walloon Excellence in Life Sciences and Biotechnology

Fonds National de la Recherche Scientifique

Action de Recherche Concertée

Wallonia-Brussels Federation

German Research Foundation

Austrian Science Fund

Netherlands Heart Foundation

Dekker Senior Clinical Scientist 2019

Norwegian Research Council