Affiliation:
1. Student Research Committee, Faculty of Public Health Branch, Iran University of Medical Sciences , Tehran, Iran
2. Department of Nutrition, School of Public Health, Iran University of Medical Sciences , Tehran, Iran
3. Medical Library and Information Science, Asadabad School Medical Sciences , Asadabad, Iran
4. Department of Nutrition, School of Public Health, Shahid Sadughi University of Medical Sciences , Yazd, Iran
Abstract
Abstract
Context
Sepsis refers to a usually lethal medical condition that results from an extreme, uncontrolled, and multifaceted immune system response to infection. Ginger (Zingiber officinale Roscoe; Zingiberaceae) is 1 of the most popular spice. It is widely used as a traditional herb and as medicine in the treatment of some inflammatory conditions, such as vomiting, pain, cancer, diabetes, and cardiovascular diseases, because of its varied medical characteristics, including anti-inflammatory, antioxidant, antimicrobial, and antitumor effects.
Objective
The aim of this study was to demonstrate the potential roles of ginger and its elements in sepsis.
Data Sources
This systematic review article was conducted and reported by following the guideline of the Preferred Reporting for Systematic Reviews (PRISMA). Electronic databases, including Web of Sciences, Google Scholar, PubMed, Scopus, and ProQuest, were searched using related key words up to January 2023.
Data Extraction
Among 141 found articles, 48 eligible articles were included and reviewed for their details. Data were extracted, including the first author's name, year of publication, name of origin country, study design, number and type of subject, dosage and type of intervention, study duration, assay, and main results.
Data Analysis
The data from the included articles showed that ginger and its bioactive elements, such as gingerol (1–300 µg/mL or 1–100 mg/kg for 24 hours to 14 days), shogaol (0.2–100 µg/mL or 10–40 mg/kg body weight for 24 hours to 8 days), gingerdione (1–100 µg/mL for 20–48 hours), and zingerone (2–20 µM for 4 hours to 8 days), can be effective in sepsis via suppressing the gene expression and production of pro-inflammatory cytokines and oxidant agents, downregulating immune response, and protecting against sepsis-induced organ failures in experimental and animal models.
Conclusion
Ginger has potential therapeutic effects in sepsis. Human clinical trials are recommended.
Systematic Review Registration
PROSPERO registration no. CRD42023373613.
Publisher
Oxford University Press (OUP)
Subject
Nutrition and Dietetics,Medicine (miscellaneous)