Effects of a high-fat diet on the bone structure of Wistar rats: a systematic review

Author:

Silva Rafael T1ORCID,Ferreira Luciana J D1,Macêdo Ana P A2,Santos Lucimeire S1ORCID,Santo Djane A E1ORCID,Codeiro Gabriele S1ORCID,Pereira Marcia U1,Medeiros Ingrid O R1,da Costa Carlos A S3,Medeiros Jairza M Barreto1

Affiliation:

1. Post-Graduate Program in Food, Nutrition, and Health, Department of nutrition, Federal University of Bahia (UFBA) are with the , Salvador, Bahia, Brazil

2. Post-Graduate Program in Nutrition, Sports and Metabolism Sciences, Laboratory Molecular Biology of Exercise at State University of Campinas (Unicamp) is with the , Campinas, São Paulo, Brazil

3. Health Care Practices Knowledge Field, at Federal University of Recôncavo da Bahia (Center for Health Sciences - CCS/UFRB) is with the , Santo Antônio de Jesus, Bahia, Brazil

Abstract

Abstract Context Saturated fats found in diets known as high-fat, cafeteria, or Western diets appear to have a negative effect on bone structure; however, few studies have focused on investigating this association, and the data available in the literature remain controversial. Objective The aim of the current review was to investigate the effects of a high-fat dietary intake on the bone structure of Wistar rats. Data Sources A search for articles was carried out in the Pubmed/MEDLINE, Web of Science, Embase, and Scopus databases. Data Extraction In total, 447 articles were found in the initial search; 5 articles were included in the systematic review, after application of the exclusion criteria. Data Analysis The review was guided by the PICOS strategy and based on the PRISMA protocol for animal reviews. Conclusion High-fat diets appear to affect bone structure of Wistar rats. Diet composition and exposure time are the factors determining the strength of the effect.

Funder

National Council for Development and Technology

Fundação de Amparo à Pesquisa do Estado da Bahia

Publisher

Oxford University Press (OUP)

Subject

Nutrition and Dietetics,Medicine (miscellaneous)

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