Concentration-Dependent Kinetics of Acetylcholinesterase Inhibition by the Organophosphate Paraoxon

Author:

Rosenfeld Clint A.,Sultatos Lester G.

Publisher

Oxford University Press (OUP)

Subject

Toxicology

Reference38 articles.

1. Aldridge, W. N., and Reiner, E. (1972). Enzyme inhibitors as substrates: Interactions of esterases with esters of organophosphorus and carbamic acids. In Frontiers of Biology, Vol. 26 (A. Neuberger and E. L. Tatum, Eds.), p. 41. North-Holland, New York.

2. Barak, D., Ordentlich, A., Bromberg, A., Kronman, C., Marcus, D., Lazor, A., Ariel, N., Velan, B., and Shafferman, A. (1995). Allosteric modulation of acetylcholinesterase activity by peripheral ligands involves a conformational transition of the anionic subsite. Biochemistry34,15444–15452.

3. Barnett, P., and Rosenberry, T. L. (1977). Catalysis by acetylcholinesterase. Acceleration of the hydrolysis of neutral acetic acid esters by certain aromatic cations. J. Biol. Chem.252,7200–7206.

4. Bigbee, J. W., Sharma, K. V., Gupta, J. J., and Dupree, J. L. (1999). Morphogenic role for acetylcholinesterase in axonal outgrowth during neural development. Environ. Health Persp.107(Suppl. 1),81–87.

5. Bolger, M. P., and Taylor, P. (1979). Kinetics of association between bisquaternary ammonium ligands and acetylcholinesterase. Evidence for two conformational states of the enzyme from stopped-flow measurements of fluorescence. Biochemistry18,3622–3629.

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