4-Nitroquinoline 1-Oxide Forms 8-Hydroxydeoxyguanosine in Human Fibroblasts through Reactive Oxygen Species

Author:

Arima Yaeno,Nishigori Chikako,Takeuchi Toru,Oka Shigenori,Morimoto Kanehisa,Utani Atsushi,Miyachi Yoshiki

Publisher

Oxford University Press (OUP)

Subject

Toxicology

Reference40 articles.

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3. Cheng, K. C., Cahill, D. S., Kasai, H., Nishimura, S., and Loeb, L. A. (1992). 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G–T and A–C substitutions. J. Biol. Chem.267,166–172.

4. Dizdaroglu, M., Olinski, R., Doroshow, J. H., and Akman, S. A. (1993). Modification of DNA bases in chromatin of intact target human cells by activated human polymorphonuclear leukocytes. Cancer Res.53,1269–1272.

5. Gomi, A., Shinoda, S., Masuzawa, T., Ishikawa, T., and Kuo, M. T. (1997). Transient induction of the MRP/GS-X pump and gamma-glutamylcysteine synthetase by 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3-nitrosourea in human glioma cells. Cancer Res.57,5292–5299.

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