Mechanistic Computational Model of Steroidogenesis in H295R Cells: Role of Oxysterols and Cell Proliferation to Improve Predictability of Biochemical Response to Endocrine Active Chemical

Mechanistic Computational Model of Steroidogenesis in H295R Cells: Role of Oxysterols and Cell Proliferation to Improve Predictability of Biochemical Response to Endocrine Active Chemical—Metyrapone

Published:2011-07-01 Issue:1 Volume:123 Page:80-93
ISSN:1096-6080
Container-title:Toxicological Sciences
language:en
Short-container-title:

Author:

Breen Miyuki,Breen Michael S.,Terasaki Natsuko,Yamazaki Makoto,Lloyd Alun L.,Conolly Rory B.

Publisher

Oxford University Press (OUP)

Subject

Toxicology

Link

http://academic.oup.com/toxsci/article-pdf/123/1/80/16850723/kfr167.pdf

Reference26 articles.

1. Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs;J. Biol. Chem.,2004

2. The vision of toxicity testing in the 21st century: moving from discussion to action;Toxicol. Sci.,2010

3. Do oxysterols control cholesterol homeostasis?;J. Clin. Invest.,2002

4. Computational model of steroidogenesis in human H295R cells to predict biochemical response to endocrine-active chemicals: model development for metyrapone;Environ. Health Perspect.,2010

5. Mechanistic computational model of ovarian steroidogenesis to predict biochemical responses to endocrine active compounds;Ann. Biomed. Eng.,2007

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