Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1–TGF-β–OTX2–SNAIL via PTEN inhibition-Reference-Cited by-同舟云学术

Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1–TGF-β–OTX2–SNAIL via PTEN inhibition

Published:2018-02-27 Issue:5 Volume:141 Page:1300-1319
ISSN:0006-8950
Container-title:Brain
language:en
Short-container-title:

Author:

Ferrucci Veronica¹²³,de Antonellis Pasqualino¹²⁴,Pennino Francesco Paolo¹²,Asadzadeh Fatemeh²,Virgilio Antonella⁵,Montanaro Donatella²,Galeone Aldo⁵,Boffa Iolanda²,Pisano Ida²,Scognamiglio Iolanda²,Navas Luigi⁶,Diana Donatella⁷,Pedone Emilia⁷,Gargiulo Sara⁷,Gramanzini Matteo⁷,Brunetti Arturo²⁸,Danielson Laura⁹,Carotenuto Marianeve¹²,Liguori Lucia²,Verrico Antonio¹⁰,Quaglietta Lucia¹⁰,Errico Maria Elena¹¹,Del Monaco Valentina²,D’Argenio Valeria¹²,Tirone Felice¹²,Mastronuzzi Angela¹³,Donofrio Vittoria¹¹,Giangaspero Felice¹⁴¹⁵,Picard Daniel¹⁶,Remke Marc¹⁶,Garzia Livia⁴¹⁷,Daniels Craig⁴,Delattre Olivier¹⁸,Swartling Fredrik J¹⁹,Weiss William A²⁰,Salvatore Francesco¹²,Fattorusso Roberto²¹,Chesler Louis⁹,Taylor Michael D⁴¹⁷,Cinalli Giuseppe¹⁰,Zollo Massimo¹²³²²

Affiliation:

1. Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università degli Studi di Napoli Federico II, Naples, Italy

2. CEINGE Biotecnologie Avanzate, Naples, Italy

3. European School of Molecular Medicine (SEMM), Milan, Italy

4. Arthur and Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, Ontario, Canada

5. Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Naples, Italy

6. Department of Veterinary Medicine and Animal Productions, Università degli Studi di Napoli Federico II, Naples, Italy

7. Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale della Ricerca, Naples, Italy

8. Dipartimento di Scienze Biomediche Avanzate, Università degli Studi di Napoli Federico II, Naples, Italy

9. Division of Clinical Studies, The Institute of Cancer Research, London SM2 5NG, UK

10. Paediatric Neurosurgery, Ospedale Santobono-Pausilipon, Naples, Italy

11. Pathology Unit, Ospedale Santobono-Pausilipon, Naples, Italy

12. Genetic Control of Development-URT, Institute of Cell Biology and Neurobiology, National Research Council, Fondazione Santa Lucia, Rome, Italy

13. Dipartimento di Onco-Ematologia, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy

14. Dipartimento di Scienze Radiologiche, Oncologiche e Anatomo Patologiche, Università La Sapienza, Rome, Italy

15. IRCCS Neuromed, Pozzilli, Italy

16. German Cancer Consortium (DKTK), Department of Paediatric Oncology, Haematology, and Clinical Immunology, University Hospital Düsseldorf, Düsseldorf, Germany

17. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto ON, Canada

18. PSL Research University, Inserm U830, Equipe Labellisée Ligue contre le Cancer, Institut Curie, Paris, France

19. Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden

20. Department of Neurology, University of California, San Francisco, San Francisco, CA, USA

21. Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Caserta, Italy

22. DAI-Medicina Trasfusionale-Azienda Ospedaliera Universitaria Federico II, Naples, Italy

Publisher

Oxford University Press (OUP)

Subject

Neurology (clinical)

Link

http://academic.oup.com/brain/article-pdf/141/5/1300/24724150/awy039.pdf

Reference78 articles.

1. OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas;Adamson;Cancer Res,2010

2. Subtle variations in Pten dose determine cancer susceptibility;Alimonti;Nat Genet,2010

3. In vivo bioluminescence imaging (BLI) using orthotopic xenografts towards patient's derived-xenograft (PDX) Medulloblastoma models;Asadzadeh;Q J Nucl Med Mol Imaging,2017

4. Gadd45a sensitizes medulloblastoma cells to irradiation and suppresses MMP-9-mediated EMT;Asuthkar;Neuro Oncol,2011

5. OTX2 represses myogenic and neuronal differentiation in medulloblastoma cells;Bai;Cancer Res,2012

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