Affiliation:
1. Department of Surgery, Gyeongsang National University Changwon Hospital , Changwon , Korea
2. Department of Surgery and Cancer Research Institute, Seoul National University Hospital , Seoul , Korea
3. Department of Pathology and Translational Genomics, Samsung Medical Centre, Sungkyunkwan University School of Medicine , Seoul , Korea
Abstract
Abstract
Background
Intraductal papillary neoplasm of the bile duct (IPNB) is a relatively rare disease and is known as one of the premalignant lesions in the biliary tract. The concept of IPNB has changed through numerous studies and is still evolving. As a lesser studied clinical entity compared with its pancreatic counterpart, intraductal papillary mucinous neoplasm, IPNB has been described in many similar terms, including biliary papillomatosis, biliary intraductal papillary–mucinous neoplasm, and papillary cholangiocarcinoma. This is based on the diversity of histopathological spectrum of IPNB.
Methods
This review investigated previous studies including original articles, case studies, and expert opinions. Recently, two types of IPNB (types 1 and 2) have been proposed and validated based on the content first established in the WHO 2010 criteria.
Results
This review provides a comprehensive analysis of existing literature, summarizing the clinical, radiological, morphological, and pathological characteristics of IPNB.
Conclusion
Given the ongoing ambiguity and controversies surrounding IPNB, future research, including large population-based studies and molecular investigations, is essential to enhance understanding of this disease.
Publisher
Oxford University Press (OUP)
Cited by
1 articles.
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