Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries
Author:
, Xu WilliamORCID, Liu Gordon, Varghese Chris, Wells Cameron, Smith Nicolas, Windsor John, Gaborit Lorane, Goh Sarah, Basam Aya, Elhadi Muhammed, Soh Rachel TingQian, Saeed Umar, Abdulwahed Eman, Farrell Michael, Wright Deborah, Martin Jennifer, Pockney Peter, Xu William, Basam Aya, Goh Sarah, Li Jiting, Shah Jainil, Waraich Abdullah, Gaborit Lorane, Pathak Upasana, Hilder Amie, Elhadi Muhammed, Jabur Aiden, Kalyanasundaram Kaviya, Ohis Christina, Ong Chui Foong, Park Melissa, Siribaddana Venesa, Raubenheimer Kyle, Vu Jennifer, Wells Cameron, Liu Gordon, Ferguson Liam, Xu William, Varghese Chris, Pockney Peter, Atherton Kristy, Dawson Amanda, Martin Jennifer, Banerjee Arnab, Dudi-Venkata Nagendra, Lightfoot Nicholas, Ludbrook Isabella, Peters Luke, Sara Rachel, Watson David, Wright Deborah, Adeyeye Ademola, Alvarez-Lozada Luis Adrian, Atici Semra Demirli, Buhavac Milos, Calini Giacomo, Elhadi Muhammed, Ioannidis Orestis, Tepe Mustafa Deniz, Nath Upanmanyu, Uzair Ahmad, Yang Wah, Zaidi Faseeh, Singh Surya, Abdullah Bahiyah, Palacios Diana Sofia Garces, Ragab Ahmed, Ahmed Ahmed, Raubenheimer Kyle, Daudu Davina, Goh Sarah, Benyani Simran Vinod, Karthikeyan Nandini, Mansour Laure Taher, Seow Warren, Tasi Zoya, Jabur Aiden, Pathak Upasana, Park Melissa, Abdelmelek Dhia Errahmane, Boussahel Ikram Fatima Zohra, Kaabache Oumelaz, Lemdaoui Naoual, Nebbar Oualid, Rais Mounira, Abdoun Meriem, Kouicem Aya Tinhinane, Bouaoud Souad, Bouchenak Kamel, Saada Hind, Ouyahia Amel, Messai Wassila, Choong Zhi Shyuan, Ting Clarissa, Larkin Michelle, Fong Pei Jun, Soh Isabel, De Grandi Alyssia, Iftikhar Hareem, Sinha Akansha, Kapoor Dhruv, Chlebicka Tara, Singer David, Goddard Kim, Matthews Lisa, Lin Rosalina, Chambers Jessica, Chan Juliet, Macnab Brooke, Barker John, Mckenzie Morgan, Ferguson Neil, Juwaheer Ghanisht, Muralidharan Vijayaragavan, Gill Sonia, Sung Nakjun, Patel Rohan, Walters Chris, Nguyen Kevin, Liu David, Cabalag Carlos, Lee Jennifer, Leow San-Hui Anita, Ng Suat Li, Ashraf Hamza, Mulder Fraizer, Loo Jonathan, Proud David, Wong Samantha, Zhou Yida, Soh Qi Rui, Chye David, Stevens Sean, Tang Patrick, Kritharides Stephen, Dong Jason, Morice Oscar, Huang Dora, Hardidge Andrew, Amarasekara Mishka, Kink Aleah, Bolton Damien, Rawal Alisha, Singh Jasraaj, Heard Matthew, Hassan Yusuf, Naqeeb Ahmed, Cobden Andrew, Prinsloo Duron, Quadros Dwain, Gunn Emma, Kim Ha Jin, Ekwebelam Jennifer, Shanahan James, Alkazali Mustafa, Hoosenally Mariyah, Nara Naveen, Nguyen Peter, Barker Sally, Hilder Amie, Hui Ally, Karmakar Antara, Wang Bill, Goonawardena Janindu, Cheung King Tung, Chan Nicholas, Natarajan Ragul, Cade Richard, Jin Rong, Sengupta Shomik, Snider Ruth, Morisetty Harsha, Weeda Lewis, Sun Phoebe, Chilaka Lalitya, Cover Jacinta, De Silva Abeweera Gunasekara Aashrinee, Senthilrajan Rahavi, Alwahaib Anas, Limmer Alexandra, Zamanbandhon Bushra, Jaffry Kumail, Shen Yijia, Chua Alan, Syed Saifulla, Saha Sushanth, Glynatsis John, Aitchison Lori, Lagana Bernard, Crossman Mason, Watson David, Dawson Abby, Fong Bryan, Harrison Ella, Horsburgh Eleanor, Glynatsis John, Khoo Michael, Mishra Kritika, Hewton Lewis, Mesecke Alex, Tu Hien, Tun Than, Wong Jason, Ong Elynn, Law Tara-Nyssa, Landy Ashlee, Leano Alyssa, Li Andrea, Soni Akshay, Dowdle Benjamin, Pilgrim Charles, Abeysirigunawardana Dewmi, Jeyarajan Deepak Rajan, Patel Diya, Chung Jason, Mckinnon Kyle, Gould Madeline, Gilmore Paul, Geng Ruxi, Loughnan Rachael, Norton-Smith Sarahjane, Nyame Solomon, Tan Sarah, Samarawickrama Sewni, Yoon Si Woo, Wang Yantong, Zhang Yichi, Wang Zixuan, Mare Hans, Withanage Indrajith, Khattar Mitali, Toft Alexandra, Sivasuthan Goutham, Zhao Hailin, Addley Jordan, O'brien Lucinda, Raza Muhammad, Bindra Randipsingh, Sharma Sonakshi, Cornwell Charlotte, Patil Aditya, Cheung Aiden, Lown Ashleigh, Dawson Amanda, Blassey Aneel, Ochigbo Benjamin, Cheng Felicity, Fatima Aleeza, Zhang Edward, Kocatekin Henry, Roth Charles, Brewster Dani, Kwok Kelvin, Chen Paul, Laura Sharon, Tynan Dominic, Latif Edward, Lun Elizabeth, Honore Elodie, Ziergiebel Felix, Blake Jessica, Chandiok Karan, Bird Katie, Ngothanh Lynette, Lee Melissa, El-Masry Mariam, Hamer Peter, Palaniappan Ramanathan Rm, Mcgee Richard, Huang Sarah, Zhang Shane, Hariharan Shubhang, De Silva Yannick, Lee Celeste, Fotheringham Penelope, Incoll Ian, Cordingley Timothy, Cheng Felicity, Brown Matthew, Kang Leannedra, Wijayaratne Rivindu, Moore Parisse, Qian Gemma, Elgindy Yara, Carnuccio Emma, Rae Hamish, Shehata Mena, Liu Mingchun, Lockwood Brodee, Van Bockxmeer John, Alsoudani Ali, Swan Daniel, Hsieh Justin, Orchard-Hall Francesca, Tay Kai Yun Jodene, Mehra Raagini, Gebeh Alpha, Bailey Ashley, Brown Georgia, Colaco Ashley, Gopal Hemashree, Boyley Jessica, Changati Varun, Fletcher Joseph, Khandelwal Tanishq, House Colin, O'neil Chris, Jaarsma Emily, Ly Victor, Balogh Zsolt, Shui Amanda, Sathasivam Vinogi, Legge-Wilkinson Hannah, Wong King Ho, Chen Andrew, Tran Anthony, Rehfisch Peter, Wang Grace, Nguyen Jonathan, Peker Joshua, Gallert Kayla, Komesaroff Mia, Namburi Manideep, Goldfinch Elisabeth, Muchabaiwa Ropafadzo, Jangam Aishwarya, Taylor Isobel, Nusem Iulian, Park Jin Hyuk (David), Gundara Justin, Heigan Rachael, Tran Tam, Mackay Thomas, Butterworth Yasmine, Sadauskas Tomas, Tung Melody, Ellepola Hasthika, Gan Christine, Fong Hakim, Das Ankita, Naicker Leshya, Hauptman Samantha, Kamath Aditi, Yew Anthea, Parange Anupam, Kim Katie, Kharwadkar Sahil, Gamage Tharushi, Vance Lucille, Seldon Alexandra, Ghaly Moheb, Phan Victoria, Chauhan Karanjeet, Bassam Ahmad, Vollenhoven Beverley, Jaffry Kumail, Mandhan Kajal, Sritharan Mithra, Sakthivel Mahesh, Evans Natalie, Robinson Samuel, Sivakumar Seiyon, Marrison Liberty, Jollow David, Joshi Krishma, Tao Steve, Shrestha Pallavi, Nukala Sai Keerthana, Hodgson Russell, Crotty Anna, Esho Adriana, Harris Alasdair, Surkitt Amy, Bland Laura, Mcleod Blake, Yin Chonghao, Keng Cambo, Greenwood Emily, Yuan Grace, Haege Emma, Wu Hongyi, Xiao Haotian, Pozzi Isabella, Fu Jeff, Ross Jessica Stott, Gentle Juliette, Gan Kathy, Chang Kelvin, Sun Kexin, Singh Madhavi, Xie Maria, Mccabe Nicholas, Slavec Mark, Clarnette Nick, Niknami Behzad, Zou Peishan, Flintoft Sean, Jayatilleke Shenuka, Sok Rumnea, Tan Suqi, Wadhwa Sanya, Swansson Will, Abulafia Daniel, Blundell Jian, Sweetapple Amie, Del Solar Caitlin, Martin Cameron, Bell David, Fernando Isuru, Chang Jared, Vanzuylekom Katie, Van Zuylekom Katie, Van Zuylekom Kate, Hobbs Katie, Liang Richard, Jabur Aiden, Tarmidi Jazmina, Ugool Mahmoud, Beatson Nicholas, Bowman Sarah, Moin Sophie, Tan Wen Po Jonathan, Chidambaram Seevakan, Gan Siang Wei, Wang Pengnan, Naicker Leshya, Kim Katie, Wang Nicole Qiwen, Kwan Yi Xin, Patil Chinmai, Joshi Divyanshu, Kamath Aditi, Hanan Aishath, Sheriff Arfaan, Duffield Jaime, Naiker Leshya, Smitham Peter, Neo Eu Ling, Chua Matthew, Prasad Shalvin, Nagaratnam Armitesh, Sammour Tarik, Lin Yuxin, Lee Christine, Hopping Eve, Jangra Muskan, Das Ankita, Lin Ken, Bunjo Zachary, Raubenheimer Kyle, Yunos Mohamed Haseef Mohamed, Yeung Kar Long, Phu Rachel, Betts Aisling, Just Benjamin, Gera Sahil, Leeson Hilary, Jamieson Jodie, Wang Katie, Luu Emily, Innes Michael, Vu Jennifer, Hong Jonathan, Dzator Stephen, Flame Aki, Jiang Vincent, Kwok Jianing, Lawrence Aaron, Meads Kate, Pearce Liam, Sarangadasa Pavatharane, Shaw Haylee, Yu Victor, Crostella ; Elizabeth, Wong James, Bobba Sriya, Muller Maddison, Hau Yin Chi Hebe, Wilson Thomas, Markovic Aleksandra, Green Jemma, Forbes Clara, Burrows Emalee, Hou Lachlan, O'sullivan Clare, Foo Jonathon, Greig Hannah, Collins A-J, Chandler Callum, Heaney Emily, Gross Hannah, Morgan Monica, Loder Rebecca, Rajesh Krishnankutty, Ananthapadmanabhan Shravankrishna, Razmi Akeedh, Vong Crystal, Pothukuchi Prasanna, Theophilus Mary, Sriranjan Roshni, Kaur Sharon, Kanczuk Marcelo, De Groot Julia, Corrigan Angela, Li Damon, Badri Danniel, Ciranni Dominico, Needi Elangovan Thaya, Clanfield Matthew, Copertino Nicolas, Rumble William, Vanguardia Maria Kristina, Lew Chen, Dennaoui Rami, Shah Jainil, Kong Joseph, Koh Imogen, Zeng Raymond, Baziotis-Kalfas Kristian, Denby Hannah, Li Andy, Tran Will, Singh Abhinav, Lin Olivia, Chau Michelle, Donaldson Olivia, Min Christina (Seojung), Ballah Shirahn, Tsui Sonia Ching Ting, Yong Nathania, Standish Lucy, Tan Sarah, Fujihara Asuka, Davies Lily, Odisho Ramin, Ravi Anjana, Collins Josh, Chandra Pooja, Abdelmeguid Rana, Singh Gopal, Feierdaiweisi Xireaili, Seneviratne Dharani, Srivastava Shambhavi, Yao Michelle, Teng Cherilyn, Chowdhury Nebula, Vidanagama Sasini, Lin Charles, Sampatha-Waduge Tharushi, Wang Erica, Yodkitydomying Chatnapa, Koh Imogen, Silverii Julia, Lam Aaron, Zeng Raymond, Solanki Krisha, Franks Angus, Edwards Liam, Atilhan Ridvan, Nandurkar Rohan, Wells Oliver, Vanguardia Kristina, King Dennis, Edwards Elton, Edwards Liam, Tran Quang, Chau Michelle, Min Seojung, Rauf Abdul, Fu Yangzirui, Haximolla Hodo, Shang Mengge, Segaran Sharrada, Wang Shelley, Sivakumar Gananadha, Sandhu Jaspreet Kaur, Mishra Neel, Hauptman Samantha, Chua Alyssa, Chene Danielle, Maddern Guy, Shaw Henry, Wang Qiwen, Pang Siyuan, Lu Christine, Fung James, Cyr Kathryn, Lu Karen, How Ming Zhou, Hu Nelson, Anderson Paul, Jakanovski Philip, Youssef Arkan, Tang Howard, Keenan Rory, Chan Alex, Canny Mitch, Tahir Farah, Egerton James, Yeung Justin, Chan Justin, Tiffany Lea, Bei Michael, Raj Mariolyn, Williams Peter, Nagpal Sakshar, Outhred Tim, Krawitz Russel, Choi Colin Chan-Min, Younus Khadijah, Giurgius Mary, Kirk Rosemary, Pegorer Amanda Gonzalez, Tang-Ieam Pattarapan, Ward Jack, Wijetunga Asanka, Zhang Caitlin, Nahm Chris, Wang Christine, Golja Damian, Jenkins Gregory, Qian Helena, Luong Jason, Nguyen Kim, Suttor Sean, Lai Sherman, Ma Vanessa, Chen Yan, Yu Hoi Hang, Lee Amos, Barbaro Antonio, Mcguinness Cameron, Maddern Guy, Young Stevie, Lim Ye Fang, Trotta Georgina, Chao Phoebe, Ding George, Fang Carol, Lu Andi, Wagaarachchi Prabhath, Cornwell Charlotte, Gojnich Amy, Stewart Peter, Dong Isabella, Wong Kenneth, Burruso Luca, Hogan Lucinda, Mcorist Nathan, Singh Ramnik, Jeyamohan Ragavi, Hou Zhen, Lai William, Taylor Emily, Palacios Diana Sofia Garces, Pantoja Maria Alejandra Nanez, Nanez Daniel Mauricio Bolanos, Hernandez Gilmer Omar Perez, Jimenez Ramirez Lia Jasmin, Mohamed Mohamed, El-Taher Ahmed Kamal, Elewa Ahmed, Soliman Mahmoud Ayman, Diab Menna, Ali Radwa, Ahmed Ahmed, Galal Adham, Elkhodary Ahmed, Alaa Ali, Faisal Arwa, Badawy Asmaa, Eldomiaty Donia, Sayed Mohamed Al, Rasslan Esraa, Ramadan Mohamed, Fares Gamal Elsayed, Altabbaa Hashem, Emad Humam, Alboridy Muneera, Mongy Mahmoud, Albarhomy Osama, Selim Osama, Rafaei Rawan, Atta Raneem, Altaweel Ahmad, Sherif Yara, Elghoul Youssef, Tarek Yousef, Sabry Ahmed Abdelfatah, Moustafa Ahmad, AbouHiekal Osama, Shaqran Osama Al, Haggag Zeyad, Abbas Ahmed M, Temerik Abdallah Rashad, Atef Dina, Mahmoud Ahmed, Saad Mahmoud M, Ragab Mohammed, Mahmoud Ahmed Omar, Hussien Aya, Abdelbaky Mostafa, Muhammad Ismail, Morad Afnan, Ali Ahmed, Hussien Ahmed, Shipa Ahmed, Aboulfotouh Ahmed, Abdelaal Ahmed M, Hashem Ahmed Mohamed, Youssef Ahmed A, Morsi Ahmed, Ebrahim Alshymaa, Sayed Ahmed M, Kamel Ali Momen, Elmaghrabey Abdallah, Elgharib Asmaa Moatasem, Abdelrahman Amira, Ali Aml, Abdelnaeam Samah, Emam Asmaa, el-mola Amira Gad, Shaban Aya, Shaltout Asmaa S, Nabil Bashayer, Barsoum Fady, Mostafa Esraa, Abdelbaset Doaa, Salah Doaa, Othman Dina, Othman Safaa, Khairallah Nour Salah, Hassan Shimaa Abbas, Morsi Salma, Azer Armia, Abdelsamed Enas Abdelbaset, Ahmed Rehab, Ibrahim Islam, AbdElbaset Esraa, Hamoda Esraa, Monib Fatma, Harb Fatma, Maher Hager, Ahmed Hatem, Mohammed Haitham, Hana Kerolous, Ayoub Kerillos, Henes Kerollos, Shamshoon Kerollos, Soliman Keroles, Hassanein Mahmoud, Abdelhamid Mohamed M, Mahdy Magdy, Khalil Mahmoud, Ali Manal, Khalifa Mansour, Amary Marwa, Suliman Merna Ezz, Abdallah Mohamed M, Nasr Mohammed Saif Al, Elia Michael, Adly Michael, Roshdy Mo'men, Ramadan Mohamed F, Shahat Mohammed A, Abdelnasser Mohammad K, Zaed Moahmed, Al-Quossi Mohammed, Zarzour Mohamed A, Hares Mohamed M, Abdelfatah Mohammed Abdelnasser, Abughanima Mahmoud, Abdeljaber Mahmoud, Saber Mona, Amin Mostafa K, Abbas Mostafa, Haroon Ola, Khalil Omaima, Talaat Omnia, Elnagar Rahma, Soliman Randa, Aboelela Reham, Salah Salem, Abdelgawad Samia, Mohammed Tasneem, Hussien Tarek A, Sobhy George, Sayed Yasmeen, Silem Yousra Othman Reham, Dawood Ali, Hemaida Tarek, Ahmed Reem, Kamaleldin Aya, Zakaria Ahmed, Salah Mohamed, Salem Ebrahim, Rashed Osama Fathy Ali Ali, Halawa Mohamed, Elfeki Hossam, Mosaad Abdelrahman, Shaaban Abdelrahman, Abdelsalam Hebatalla, Sakr Ahmed, Sanad Aly, Elsawy Amr, Maged Bassant Maged, Hegazy Dana, Abdelmaksoud Mohamed, Laymon Mahmoud, Taman Mohamed, Moawad Esraa R, AboElfarh Hadeer Elsaeed, Elkenawi Karim, Osama Manar, Sadek Mirna, Elghazy Mohamed Abdelaziz, Attia Mohamed, Nader Mohamed, Shalaby Mostafa, Attiya Omar, Gaarour Osama Samir, Zaghloul Ahmed, Mikhail Pola, Badr Karim, Soltan Hatem, Donia Mohamed, Gaafar Mohammed, Abdelwahab Khaled, Sallam Abdelaziz, Eid Ahmed, Yousri Mohamed, Hamdy Omar, Al-Touny Aiman, Alshawadfy Abdelrhman, Hamdy Ahmed, Ellilly Ahmed, Mahdy Ahmed, El-Sakka Ahmed, Hendawy Hamdy, Salah Asmaa, Raslan Bassma, Teema Eman, Albayadi Eslam, Nasser Esraa, Mohamed Hanaa, Mahmoud Mohamed, Elsaied Mostafa, Taha Omima, Dahshan Shaimaa, Al-Touny Shimaa, Karrar Ahmed, Khairy Ahmed, Farag Abdelrahman, Deafallah Asmaa, Ads Alaa Mohamed, Alomar Rabiaa, AbuShawareb Issa, Saeed Abdallah, Mashaal Abdelhafeez, Ads Adel Mohamed, Ghanem Sohila, Elghamry Ahmed, Nada Eman Ayman, Noureldin Youssef Ali, Fouda Mohamed Fayez, Shaheen Nourhan, Allam Shereen, Mazrou Ibrahim, Shehab Ali Fahmy, Kussaili Wesam, Korkolis Dimitrios, Fradelos Evangelos, Sarafi Aikaterini, Machairas Nikolaos, Giannakopoulos Konstantinos S, Stavratis Fotios, Korovesis Georgios, Tsourouflis Gerasimos, Keramida Myrto D, Kydonakis Nikolaos, Kykalos Stylianos, Syllaios Athanasios, Dorovinis Panagiotis, Schizas Dimitrios, Ioannidis Orestis, Malliora Anastasia, Anestiadou Elissavet, Zapsalis Konstantinos, Kontidis Fotios, Loutzidou Lydia, Ouzounidis Nikolaos, Bitsianis Stefanos, Symeonidis Savvas, Skalidou Smaragda, Ioannidis Orestis, Valaroutsou Olga Maria, Dagklis Themistoklis, Arvanitaki Alexandra, Mamopoulos Apostolos, Athanasiadis Apostolos, Kopatsaris Stergios, Kalogiannidis Ioannis, Tsakiridis Ioannis, Kapetanios Georgios, Papanikolaou Evangelos, Tsakiridis Nikolaos, Zachomitros Fotios, Larentzakis Andreas, Gyftopoulos Argyrios, Albanopoulos Konstantinos, Champipis Apostolos, Yiannakopoulos Christos, Vrakopoulou Gavriella Zoi, Saliaris Konstantinos, Lathouras Konstantinos, Skoufias Spyridon, Doulami Georgia, Bareka Metaxia, Arnaoutoglou Eleni, Angelis Fragkiskos, Angeslis Fragkiskos, Hantes Michael, Ntalouka Maria, Al-Juaifari Maytham A, Alwash Mohammed, Maala Rasool, Zwain Yasir Adnan, Saleh Sara Ahmed, Khorsheed Mohammed, Pesce Antonio, Feo Carlo V, Bernabei Massimiliano, Petrarulo Francesca, Fabbri Nicolò, Labriola Raffaele, Barbara Silvia Jasmine, Bosi Simone, Romano Angela, Canavese Anna, Catalioto Caterina, Isopi Claudio, Larotonda Cristina, Dajti Gerti, Rottoli Matteo, Russo Iris Shari, Cardelli Stefano, Castagnini Francesco, Traina Francesco, Guizzardi Giulia, Giuzzardi Giulia, Gorgone Mara, Maestri Marco, Cianci Pasquale, Conversano Ivana, Restini Enrico, Gattulli Domenico, Grillea Giorgia, Varesano Marco, Calini Giacomo, Andriani Adelaide, Gattesco Davide, Terrosu Giovanni, Zambon Mattia, Cerinic Pietro Matucci, Moretti Luisa, Muschitiello Davide, Polo Samantha, Bresadola Vittorio, Wardeh Salah Abu, Al-Baw Mahmoud, Alhaleeq Saif, Al-Issawi Subhi, Alsaify Esmat, Banihani Farah, Massadeh Noor, Massadeh Nada, Al-issawi Dima, Elyan Basel, Al-Shami Qotadah, Alomari Yazan, Khamees Almu'atasim, Al-Tahayneh Sief-Addeen, Alsheik Ahmad, Sawaftah Khaled, Sarhan Osama, Alkhatib Abed Alazeez, Alzghoul Bader, 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Alzarroug Amal, Alabed Ebtihal, Elreaid Fadwa, Elkharaz Omar A, Elreaid Fatma Fathi, Albatni Safa Sasi, Elmehdawi Haitham, Gahwagi Milad, Mohamed Ayman, Alfrjani Tariq, Khafifi Khaled, Rasheed Ayat, Akwaisah Ayoub, Bushaala Hassan, Elfadli Mustafa, Moftah Mohamed, Algabbasi Salima, Esaiti Salma, Elfallah Sara, Alharam Abtisam, Alariby Fatima, Isweesi Mohamed, Eldarat Tarik Ahmed, Dabas Ayman Arhuma, Alkaseek Akram, Abodina Ahmed Mohammed, Alqaarh Aya, Bakeer Hibah Bileid, Alhaddad Hoda Salem, Aboudlal Husein, Alsaih Sawsan, Abubaker Noora, Abdelrahim Najwa, Alzarga Ali, Omar Basma, Faris Farah, Alhadad Qamrah, Abufanas Asma, Badi Hussameddin, Benismai Israa, Obeid Hawa, Abdalei Abdulwahab, Abdulrahman Ahmed, Swalem Aisha, Alzarouq Ebtisam, Safar Amna, Shagroun Esra, Hashem Boshra, Elrishi Fatheia, Abdulali Fatima, Ahmed Habeeba, Eltaib Ibrahim, Elzoubia Joma, Albarki Aisha, El Mugassabi Hoda, Abushaala Fatima, Abuzaho Amany, Juha Nida, Egzait Raneem, Shetwan Sundes, Lemhaishi Alzahra, Matoug Faisel, Abdulwahed Eman, Askar Aamal, Ashur Abir Ben, Bezweek Adel, Altughar Bushra, Emhimmed David, Elferis Donia, Elgherwi Laila, Soula Enas, Gidiem Doaa, Grada Maren, Derwish Khawla, Alameen Maram, Algatanesh Nassib, Elkheshebi Ahlam, Ghmagh Reem, Barka Sharf, Ahmeed Sultan, Aljamal Sarah, Alragig Zahra, Addalla Mohamed, Atia Ahmed, Kharim Atab, Mahmoud Fathia, Binnawara Muhannud, Alshareea Entisar, Alsori Mohamed, Alshawesh Aisha, Alrifae Ghaliya Mohamed H, Ashour Amira, Abozid Anwaar, Alflite Asil Omar Saleh, Mohamed Anwar, Arebi Jaber, Alagelli Fatma, Gineeb Hana Yousef, Ghmagh Rawia, Omar Rihab Mohammed Bin, Alaqoubi Retaj, Mohammed Sara, Bensalem Serien Hossain, Elgadi Tahani, Sami Wesam, Bariun Yara, Alhashimi Abdulhadi Mohammed Alhadi, Abdulla Dheba Almukhtar, Rhuma Heba, Enaami Husam, Alboueishi Asraa Ali, Alkchr Hayat Ben Hasan Mohamed A A, Albakosh Bashir Abobaker, Hasan Najat Ben, Alsari Najah, Aldreawi Mohammed, Abushanab Khaled, Yahya Rawad, Samalavicius Narimantas, Eismontas Vitalijus, Jurgaitis Jonas, Aliosin Oleg, Nutautiene Vitalija, Zakaria Andee Dzulkarnaen, Pillai Anil Kumar Sree Kumar, Vadioaloo Dinesh Kumar, Daud Mohamed Ashraf Mohamed, Soh Jien Yen, Zakaria Mohd Zaim, Rusli Siti Mayuha, Ashar Nur Ayuni Khirul, Ahmad Zatul Akmar, Ramlee Afiq Aizat, Alsagoff Sharifah Nor Amirah Syed Abdul Latiff, Sofian Ahmad Anuar, Jamil Muhammad Badrul Hisyam Mohamad, Abdullah Bahiyah, Noorman Mohamad Faiz, Abidin Muhammad Fihmi Zainal, Isahak Mohamed Izzad, Adnan Siti Nasyirah Nisya, Noor Zaidatul Husna Mohamad, Alvarez-Lozada Luis Adrian, Garza Alejandro Quiroga, Leal Andrea Aguilar, Reyes Bernardo Alfonso Fernández, Guerra Ethel Valeria Orta, Garza Francisco Javier Arrambide, Mey Héctor Erasmo Alcocer, Isais Jorge Arath Rosales, Zertuche Juventino Tadeo Guerrero, García Patricia Ludivina González, Sánchez Luis Antonio Heredia, Mercado Marcela Patricia Flores, Sierra Oscar Alonso Verduzco, Morales Pedro Emiliano Ramos, Fuentes Stephie Oyervides, Martínez Víctor Manuel Peña, Guerra-Juárez Yesika Alejandra, Flores-González Ana Karina, Singh Surya, Hadi Arwa, Woodbridge Christian, Thornton-Hume David, Forsythe Jack, Dharmaratne Isini, Pai Vivian, Windsor John, Zargar Kamran, Waldin Lucy, Winthrop Lily, Alvarez Matias, Huang Meileen, Kumove Matt, Simonetti Marta, Chand Namisha, Goldsmith Oliver, Guo Oscar, Monk Paul, Zhou Karen, Penneru Sai Harshitha, Prasad Shaamnil, Ren Seifei, Hill Terrence, Mistry Vyoma, Sun Selena, Pereira Ashley, Mclaughlin Scott, Stokes Andrew, Sathiyaseelan Avinash, Rossaak Jeremy, Lim Janice, Brooke Kenya, Quinlan Liam, Pottier Mark, Podder Nayanika, Jinu Puja, Ramphal Shanay, Vermeulen Wikus, Ordones Flavio, Jeffery Fraser, Busaidi Ibrahim S Al, Divinagracia Janelle, Ju William, Liu Yizhuo, Glyn Tamara, Thompson Nasya, Graziadei Vivien, Canton Joshua, Furey Joseph, Choi Horim, Coomber Grace, Divekar Tanya, English Tessa, Gernhoefer Erin, Healy Tom, Chou Justin, Parajuli Dikshya, Reed Catherine, Studd Rod, Lin Anthony, Wells Cameron, Xu Cindy, Hadi Arwa, Maccormick Andrew, Park Heejun, Rathnayake Athulya, Williams Brittany, Chan Ashley, Smith Corinne, Casciola Francesca, Bhikha Jainey, Luo Jonathan, Yi Kevin, Singhal Megan, George Ria, Luo Rosie, Frost Taylor, Hakak Fatima, George Akhita, Carlos Angela, Ho Annie, Mcrae Connor, Lescheid Jonathan, Soek Jenny, Pham Andrew, Clair Sophie St, Yee Su-Ann, Lim Jennifer, Wu Chun-Yen, Kim Taehoon, Chua Anne Qi, Harmston Christopher, Boyes Hamish, Cook Holly, Struthers Jamie, Radovanovich Jess, Quek Nicholas, Fearnley-Fitzgerald Chekodi, Wright Deborah, Ghandi Kushan, Matheson Natalie, McGuinness Matthew James, Chen Brian, Douglas Rebecca Indiana, Richter Konrad, Soliman Nisha Bianca, Bolam Scott Matthew, Vimalan Vineeth, Currie William, Cuthbert Mitchell, Ross Poppy, Nicholson Amy, Garton Briar, Agnew Emilie, Conlon Niamh, Waaka Nicholas, Kejriwal Ritwik, Nguyen Sean, Leung Edmund, Ratnayake Milidu, Smith Quintin, Joseph 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Benamor Oumayma, Chakroun Sawssen, Sanli Ahmet Necati, Yildiz Ahmet, Demirkiran Mehmet Ali, Atadag Yildiz Buyukdereli, Tandogan Yusuf Iskender, Ozkan Esin, Ozer Yıldırım, Ozkan Esin, Oncel Muhammed Miran, Kalkan Senad, Gover Tolga, Manoglu Berke, Oksak Ilayda, Kurt Ipek, Rifaioglu Kerem, Sokmen Selman, Bisgin Tayfun, Yildirim Yasemin, Keskin Abdil Yetkin, Dogan Tugce, Sahin Berfin İlgaz, Aydin Cemil, Benek Duygu Ece, Tiras Hale Nur, Arslangilay Mert, Aslangilay Mert, Yaytokgil Muhammet, Capar Mehmet Ali, Yazgan Yasemin, Bektas Sebnem, Alagoz Ahmet Can, Dagsali Alara Ece, Izgis Aylin, Uzel Kadir, Soytas Mustafa, Cakir Niyazi, Askin Abdullah Emre, Azboy Ibrahim, Sabuncu Kubilay, Aslan Merve, Sahin Melek, Oncel Mustafa, Okkabaz Nuri, Sivrikaya Ramazan Kemal, Saylar Alparslan, Saylar Alparslan, Yasar Meltem, Erginoz Ergin, Bozkir Haktan Ovul, Zengin Kagan, Ozcelik Mehmet Faik, Uludag Server Sezgin, Ozdemir Zeynep, Sibic Osman, Telci Hatice, Bozkurt Mehmet Abdussamet, Kara Yasin, Tepe 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Elif, Tuzuner Filiz, Hokelekli Furkan, Mutlu Mucahid, Akbuz Seyma Orcan, Kus Ziya Can, Kus Ziya Can, Farrell Michael, Craig-Lucas Alayna, Painter Matthew, Titan Ashley, Narayan Aditya, Fariyike Bunmi, Knowlton Lisa, Yue Tiffany, Benham Emily, Nimeri Abdelrahman, Werenski Hope, Kaiser Nicole, Reinke Caroline
Abstract
Abstract
Background
Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.
Methods
This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.
Results
The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1–30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80–100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (β coefficient 0.92, 95% c.i. −1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.
Conclusion
Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely.
Funder
Maurice and Phyllis Paykel Trust Surgical Research Funds, University of Newcastle, Australia.
Publisher
Oxford University Press (OUP)
Cited by
5 articles.
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