Electrical dysfunctions in human-induced pluripotent stem cell-derived cardiomyocytes from a patient with an arrhythmogenic right ventricular cardiomyopathy

Author:

El-Battrawy Ibrahim12,Zhao Zhihan12,Lan Huan123,Cyganek Lukas24,Tombers Christoph1,Li Xin1,Buljubasic Fanis12,Lang Siegfried12,Tiburcy Malte25,Zimmermann Wolfram-Hubertus25,Utikal Jochen267,Wieland Thomas28,Borggrefe Martin12,Zhou Xiao-Bo123,Akin Ibrahim12

Affiliation:

1. First Department of Medicine, Faculty of Medicine, University Medical Centre Mannheim (UMM), University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany

2. DZHK (German Center for Cardiovascular Research), Partner Site, Heidelberg-Mannheim and Göttingen, Mannheim, Germany

3. Key Laboratory of Medical Electrophysiology of Ministry of Education, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan, China

4. Stem Cell Unit, Heart Research Center Göttingen, Göttingen, Germany

5. Institute of Pharmacology and Toxicology, University of Göttingen, Göttingen, Germany

6. Skin Cancer Unit, German Cancer Research Center (DKFZ), Heidelberg

7. Department of Dermatology, Venereology and Allergology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany

8. Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany

Funder

DZHK

BMBF

Publisher

Oxford University Press (OUP)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference22 articles.

1. Sex differences in cardiomyopathies;Meyer;Eur J Heart Fail,2014

2. Arrhythmogenic right ventricular cardiomyopathy/dysplasia: a not so rare “disease of the desmosome” with multiple clinical presentations;Herren;Clin Res Cardiol,2009

3. Intercalated disc abnormalities, reduced Na(+) current density, and conduction slowing in desmoglein-2 mutant mice prior to cardiomyopathic changes;Rizzo;Cardiovasc Res,2012

4. Arrhythmogenic right ventricular cardiomyopathy/dysplasia: an update;Calkins;Curr Cardiol Rep,2008

5. Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs;Kim;Nature,2013

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