Specific Redistribution of Severe Acute Respiratory Syndrome Coronavirus 2 Variants in the Respiratory System and Intestinal Tract

Author:

Du Pengcheng12,Song Chuan12,Li Rui12,Song Yangzi12,Li Jiarui12,Ding Nan12,Zhang Ju12,Song Rui3,Han Junyan12,Gao Guiju3,Yue Jinglin12,Duan Ang12,Huang Yanyi4,An Jing5,Wang Jianbin6,Zhang Fujie3,Chen Chen12,Zeng Hui12

Affiliation:

1. Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China

2. Beijing Key Laboratory of Emerging Infectious Diseases, Beijing, People’s Republic of China

3. Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People’s Republic of China

4. Biomedical Pioneering Innovation Center, Beijing Advanced Innovation Center for Genomics, College of Chemistry and Molecular Engineering, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, People’s Republic of China

5. Department of Microbiology, School of Basic Medical Science, Capital Medical University, Beijing, People’s Republic of China

6. School of Life Sciences, Beijing Advanced Innovation Center for Structural Biology, Chinese Institute for Brain Research, Tsinghua University, Beijing, People’s Republic of China

Abstract

Abstract Intrahost analysis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genomic sequences identified 2 viral haplotypes comprised of 3 genetically linked mutations from the respiratory and intestinal tracts of a patient with coronavirus disease 2019. Spatiotemporal data suggest that this patient initially had dual infection of 2 SARS-CoV-2 variants, which subsequently redistributed into the 2 systems.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Reference12 articles.

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5. Presence of live SARS-CoV-2 virus in feces of coronavirus disease 2019 (COVID-19) patients: a rapid review;Sehmi;medRxiv [Preprint]. June 29,,2020

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