Sex-Specific Quantitative Trait Loci Govern Susceptibility to Theiler’s Murine Encephalomyelitis Virus-Induced Demyelination-Reference-Cited by-同舟云学术

Sex-Specific Quantitative Trait Loci Govern Susceptibility to Theiler’s Murine Encephalomyelitis Virus-Induced Demyelination

Published:2003-03-01 Issue:3 Volume:163 Page:1041-1046
ISSN:1943-2631
Container-title:Genetics
language:en
Short-container-title:

Author:

Butterfield Russell J¹,Roper Randall J¹,Rhein Dominic M¹,Melvold Roger W²,Haynes Lia³,Ma Runlin Z¹,Doerge R W⁴,Teuscher Cory⁵

Affiliation:

1. Department of Veterinary Pathobiology, University of Illinois, Urbana, Illinois 61802

2. Department of Microbiology and Immunology, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota 58202

3. Department of Microbiology-Immunology, Northwestern University Medical School, Chicago, Illinois 60611

4. Department of Statistics, Purdue University, West Lafayette, Indiana 47907

5. Department of Medicine, University of Vermont, Burlington, Vermont 05405

Abstract

Abstract Susceptibility to Theiler’s murine encephalomyelitis virus-induced demyelination (TMEVD), a mouse model for multiple sclerosis (MS), is genetically controlled. Through a mouse-human comparative mapping approach, identification of candidate susceptibility loci for MS based on the location of TMEVD susceptibility loci may be possible. Composite interval mapping (CIM) identified quantitative trait loci (QTL) controlling TMEVD severity in male and female backcross populations derived from susceptible DBA/2J and resistant BALBc/ByJ mice. We report QTL on chromosomes 1, 5, 15, and 16 affecting male mice. In addition, we identified two QTL in female mice located on chromosome 1. Our results support the existence of three linked sex-specific QTL on chromosome 1 with opposing effects on the severity of the clinical signs of TMEV-induced disease in male and female mice.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/genetics/article-pdf/163/3/1041/42048985/genetics1041.pdf

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