Mechanisms of mitochondrial reorganization

Author:

Maruyama Tatsuro1,Hama Yutaro12,Noda Nobuo N12ORCID

Affiliation:

1. Institute of Microbial Chemistry (BIKAKEN) , 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan

2. Hokkaido University Institute for Genetic Medicine, , Kita 15, Nishi 7, Kita-ku, Sapporo 060-0815, Japan

Abstract

Abstract The cytoplasm of eukaryotes is dynamically zoned by membrane-bound and membraneless organelles. Cytoplasmic zoning allows various biochemical reactions to take place at the right time and place. Mitochondrion is a membrane-bound organelle that provides a zone for intracellular energy production and metabolism of lipids and iron. A key feature of mitochondria is their high dynamics: mitochondria constantly undergo fusion and fission, and excess or damaged mitochondria are selectively eliminated by mitophagy. Therefore, mitochondria are appropriate model systems to understand dynamic cytoplasmic zoning by membrane organelles. In this review, we summarize the molecular mechanisms of mitochondrial fusion and fission as well as mitophagy unveiled through studies using yeast and mammalian models.

Funder

Tokyo Biochemical Research Foundation

Takeda Science Foundation

CREST, Japan Science and Technology Agency

JSPS KAKENHI

Publisher

Oxford University Press (OUP)

Subject

Molecular Biology,Biochemistry,General Medicine

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