Impact of Seasonal Coronavirus Antibodies on Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Responses in Solid Organ Transplant Recipients-Reference-Cited by-同舟云学术

Impact of Seasonal Coronavirus Antibodies on Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Responses in Solid Organ Transplant Recipients

Published:2022-09-01 Issue:3 Volume:76 Page:e495-e498
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Karaba Andrew H¹^ORCID,Zhou Weiqiang²,Li Shuai²,Aytenfisu Tihitina Y¹,Johnston Trevor S¹,Akinde Olivia³,Eby Yolanda³,Abedon Aura T⁴,Alejo Jennifer L⁴,Qin Caroline X⁴,Thompson Elizabeth A¹,Garonzik-Wang Jacqueline M⁵,Blankson Joel N¹,Cox Andrea L¹⁶⁷,Bailey Justin R¹,Klein Sabra L⁶,Pekosz Andrew⁶^ORCID,Segev Dorry L⁴⁸,Tobian Aaron A R³,Werbel William A¹

Affiliation:

1. Department of Medicine, Johns Hopkins University School of Medicine , Baltimore, Maryland , USA

2. Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health , Baltimore, Maryland , USA

3. Department of Pathology, Johns Hopkins University School of Medicine , Baltimore, Maryland , USA

4. Department of Surgery, Johns Hopkins University School of Medicine , Baltimore, Maryland , USA

5. Department of Surgery, University of Wisconsin School of Medicine and Public Health , Madison, Wisconsin , USA

6. W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health , Baltimore, Maryland , USA

7. Bloomberg Kimmel Institute for Cancer Immunotherapy, Johns Hopkins University School of Medicine , Baltimore, Maryland , USA

8. Department of Surgery, NYU Grossman School of Medicine , New York, New York , USA

Abstract

Abstract Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination are reduced in solid organ transplant recipients (SOTRs). We report that increased levels of preexisting antibodies to seasonal coronaviruses are associated with decreased antibody response to SARS-CoV-2 vaccination in SOTRs, supporting that antigenic imprinting modulates vaccine responses in SOTRs.

Funder

National Cancer Institute

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of Allergy and Infectious Diseases

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

Link

https://academic.oup.com/cid/advance-article-pdf/doi/10.1093/cid/ciac652/45634734/ciac652.pdf

Reference15 articles.