Persistent Circulating Severe Acute Respiratory Syndrome Coronavirus 2 Spike Is Associated With Post-acute Coronavirus Disease 2019 Sequelae-Reference-Cited by-同舟云学术

Persistent Circulating Severe Acute Respiratory Syndrome Coronavirus 2 Spike Is Associated With Post-acute Coronavirus Disease 2019 Sequelae

Published:2022-09-02 Issue:3 Volume:76 Page:e487-e490
ISSN:1058-4838
Container-title:Clinical Infectious Diseases
language:en
Short-container-title:

Author:

Swank Zoe¹²³,Senussi Yasmeen¹²³,Manickas-Hill Zachary⁴,Yu Xu G¹⁴⁵,Li Jonathan Z¹⁵,Alter Galit⁴⁶,Walt David R¹²³^ORCID

Affiliation:

1. Harvard Medical School , Boston, Massachusetts , USA

2. Department of Pathology, Brigham and Women's Hospital , Boston, Massachusetts , USA

3. Wyss Institute for Biologically Inspired Engineering, Harvard University , Boston, Massachusetts , USA

4. Ragon Institute of MGH, MIT and Harvard , Cambridge, Massachusetts , USA

5. Division of Infectious Diseases, Brigham and Women's Hospital , Boston, Massachusetts , USA

6. Division of Infectious Diseases, Massachusetts General Hospital , Boston, Massachusetts , USA

Abstract

Abstract The diagnosis of postacute sequelae of coronavirus disease 2019 (PASC) poses an ongoing medical challenge. To identify biomarkers associated with PASC we analyzed plasma samples collected from PASC and coronavirus disease 2019 patients to quantify viral antigens and inflammatory markers. We detect severe acute respiratory syndrome coronavirus 2 spike predominantly in PASC patients up to 12 months after diagnosis.

Funder

NIH

Moderna Inc.

Gates Foundation

Pfizer

Sanofi

Janssen

Abbvie

Medicago Inc.

Gilead

GlaxoSmithKline

Publisher