Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)

Author:

McDonald L Clifford1,Gerding Dale N2,Johnson Stuart23,Bakken Johan S4,Carroll Karen C5,Coffin Susan E6,Dubberke Erik R7,Garey Kevin W8,Gould Carolyn V1,Kelly Ciaran9,Loo Vivian10,Shaklee Sammons Julia6,Sandora Thomas J11,Wilcox Mark H12

Affiliation:

1. Centers for Disease Control and Prevention, Atlanta, Georgia

2. Edward Hines Jr Veterans Administration Hospital, Hines

3. Loyola University Medical Center, Maywood, Illinois

4. St Luke’s Hospital, Duluth, Minnesota

5. Johns Hopkins University School of Medicine, Baltimore, Maryl

6. Children’s Hospital of Philadelphia, Pennsylvania

7. Washington University School of Medicine, St Louis, Missouri

8. University of Houston College of Pharmacy, Texas

9. Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts

10. McGill University Health Centre, McGill University, Montréal, Québec, Canada

11. Boston Children’s Hospital, Massachusetts

12. Leeds Teaching Hospitals NHS Trust, United Kingdom

Abstract

Abstract A panel of experts was convened by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) to update the 2010 clinical practice guideline on Clostridium difficile infection (CDI) in adults. The update, which has incorporated recommendations for children (following the adult recommendations for epidemiology, diagnosis, and treatment), includes significant changes in the management of this infection and reflects the evolving controversy over best methods for diagnosis. Clostridium difficile remains the most important cause of healthcare-associated diarrhea and has become the most commonly identified cause of healthcare-associated infection in adults in the United States. Moreover, C. difficile has established itself as an important community pathogen. Although the prevalence of the epidemic and virulent ribotype 027 strain has declined markedly along with overall CDI rates in parts of Europe, it remains one of the most commonly identified strains in the United States where it causes a sizable minority of CDIs, especially healthcare-associated CDIs. This guideline updates recommendations regarding epidemiology, diagnosis, treatment, infection prevention, and environmental management.

Funder

Agency for Health Research and Quality

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Microbiology (medical)

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