Eighteen-Month Outcomes Among Pregnant and Nonpregnant Reproductive-Aged People Hospitalized for Coronavirus Disease 2019

Author:

Bebell Lisa M1ORCID,Woolley Ann E2,James Kaitlyn E3,Kim Andy2,Joyc Mary-Ruth2,Gray Kathryn J4ORCID,Radford Caitlin2,Bassett Ingrid V1ORCID,Boatin Adeline A3ORCID,Ciaranello Andrea L1ORCID,Yawetz Sigal2,Edlow Andrea G35,Goldfarb Ilona T3ORCID,Diouf Khady6

Affiliation:

1. Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Harvard Medical School , Boston, Massachusetts , USA

2. Department of Medicine, Division of Infectious Disease, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts , USA

3. Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School , Boston, Massachusetts , USA

4. Department of Obstetrics and Gynecology, University of Washington School of Medicine , Seattle, Washington , USA

5. Vincent Center for Reproductive Biology, Massachusetts General Hospital , Boston, Massachusetts , USA

6. Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Harvard Medical School , Boston, Massachusetts , USA

Abstract

Abstract Background Physiologic and immunologic adaptations in pregnancy may increase the risk of adverse outcomes from respiratory viral infections. However, data are limited on longer-term outcomes after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in pregnancy prior to widespread vaccine availability. Methods Using electronic health record data, we retrospectively compared 6-, 12-, and 18-month outcomes including death and rehospitalization between pregnant and nonpregnant reproductive-aged individuals hospitalized for SARS-CoV-2 infection between 2020 and 2021 at 2 academic referral hospitals. Results There were 190 nonpregnant and 70 pregnant participants. Mean age was 31 years for pregnant and 34 years for nonpregnant participants. For pregnant patients, mean gestational age at coronavirus disease 2019 (COVID-19) diagnosis was 36 weeks, 54% delivered by cesarean, and 97% delivered a live birth. Compared to pregnant participants, nonpregnant participants had a higher prevalence of baseline comorbidities and a higher proportion received mechanical ventilation (84% vs 55%). Index hospitalization complications (31% vs 17%) and mortality (3% vs 0%) were more common in nonpregnant participants. Over 18 months following index hospitalization, 39 (21%) nonpregnant and 5 (7%) pregnant participants were readmitted, most for infection (28/44 [64%]). Most readmissions occurred within 6 months. There were no posthospitalization deaths in the pregnant group. Conclusions Pregnant people with severe COVID-19 disease had a low rate of severe adverse outcomes after index hospitalization. The low readmission rate is reassuring that pregnant individuals may not be at higher risk for long-term severe adverse health outcomes after COVID-19 compared to the nonpregnant reproductive-aged population, possibly because any increased risk conferred by pregnancy resolves soon after delivery.

Funder

NIH

National Heart, Lung, and Blood Institute

National Institute of Allergy and Infectious Diseases

Eunice Kennedy Shriver

National Institute of Child Health and Human Development

Publisher

Oxford University Press (OUP)

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3