The Association of Human Leukocyte Antigen and COVID-19 in Southern China-Reference-Cited by-全球学者库

The Association of Human Leukocyte Antigen and COVID-19 in Southern China

Published:2021-08-06 Issue:9 Volume:8 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Yu Xueping¹,Ho Kuoting²³,Shen Zhongliang⁴,Fu Xiaoying²,Huang Hongbo⁵,Wu Delun²,Lin Yancheng²,Lin Yijian⁵,Chen Wenhuang¹,Su Milong⁶,Qiu Chao⁴,Zhuang Xibin⁵,Su Zhijun¹

Affiliation:

1. Department of Infectious Disease, The First Hospital of Quanzhou, affiliated to Fujian Medical University, Quanzhou, Fujian, China

2. HI. Q Biomedical Laboratory, Quanzhou, Fujian, China

3. School of Biomedical Science, Huaqiao University, Quanzhou, Fujian, China

4. Department of Infectious Disease, Huashan Hospital, Fudan University, Shanghai, China

5. Department of Respiratory Disease, The First Hospital of Quanzhou, affiliated to Fujian Medical University, Quanzhou, Fujian, China

6. Department of Clinical Laboratory, The First Hospital of Quanzhou, affiliated to Fujian Medical University, Quanzhou, Fujian, China

Abstract

Abstract Human leukocyte antigen (HLA) polymorphism is hypothesized to be associated with diverse immune responses toward infectious diseases. Herein, by comparing against multiple subpopulation groups as control, we confirmed that HLA-B*15:27 and HLA-DRB1*04:06 were associated with coronavirus disease 2019 susceptibility in China. Both alleles were predicted to have weak binding affinities toward viral proteins.

Funder

Young and Middle-aged Talents Training Project of Fujian Health Commission

Natural Science Foundation of Fujian Province

High-level Talent Innovation Project of Quanzhou

Science and Technology Pilot Project of Fujian Province

Science and Technology Innovation Joint Project of Fujian Province

Science and Technology Project of Quanzhou

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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