Optimal Frequency of Hepatitis C Virus (HCV) RNA Testing for Detection of Acute HCV Infection Among At-risk People With Human Immunodeficiency Virus: A Multicenter Study

Author:

Sun Hsin-Yun1ORCID,Liou Bo-Huang2,Chen Tun-Chieh34,Yang Chia-Jui56,Huang Sung-Hsi78,Lu Po-Liang4,Huang Chung-Hao4,Tsai Mao-Song5,Cheng Shu-Hsing910,Lee Nan-Yao11,Ko Wen-Chien11,Chen Yen-Hsu12,Liu Wang-Da113,Lin Shang-Yi4,Lin Shih-Ping14,Chen Po-Lin11,Syue Ling-Shan11,Huang Yu-Shan1,Chuang Yu-Chung1,Chen Cheng-Bin9,Chang Ya-Ting4,Lee Yuan-Ti1516,Hsieh Szu-Min1ORCID,Su Li-Hsin1,Cheng Chien-Yu917,Hung Chien-Ching1818ORCID

Affiliation:

1. Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine , Taipei , Taiwan

2. Department of Internal Medicine, Hsinchu MacKay Memorial Hospital , Hsinchu , Taiwan

3. Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital , Kaohsiung , Taiwan

4. Department of Internal Medicine, Kaohsiung Medical University Hospital and College of Medicine, Kaohsiung Medical University , Kaohsiung , Taiwan

5. Department of Internal Medicine, Far Eastern Memorial Hospital , New Taipei City , Taiwan

6. School of Medicine, National Yang Ming Chiao Tung University , Taipei , Taiwan

7. Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch , Hsinchu , Taiwan

8. Department of Tropical Medicine and Parasitology, National Taiwan University College of Medicine , Taipei , Taiwan

9. Department of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare , Taoyuan , Taiwan

10. School of Public Health, Taipei Medical University , Taipei , Taiwan

11. Department of Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan , Taiwan

12. School of Medicine, College of Medicine, National Sun Yat-Sen University , Kaohsiung , Taiwan

13. Department of Internal Medicine, National Taiwan University Cancer Center , Taipei , Taiwan

14. Department of Internal Medicine, Taichung Veterans General Hospital , Taichung , Taiwan

15. Department of Internal Medicine, Chung Shan Medical University Hospital , Taichung , Taiwan

16. School of Medicine, Chung Shan Medical University , Taichung , Taiwan

17. School of Public Health, National Yang Ming Chiao Tung University , Taipei , Taiwan

18. Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch , Yun-Lin , Taiwan

Abstract

Abstract Using 3-stage pooled-plasma hepatitis C virus (HCV) RNA testing performed quarterly among at-risk people with human immunodeficiency virus (PWH), we found that if testing had been performed every 6 or 12 months, 58.6%–91.7% of PWH who recently acquired HCV would be delayed for diagnosis and might contribute to onward HCV transmission with longer durations.

Funder

National Taiwan University Hospital

Gilead Sciences

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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