Association Between SARS-CoV-2 Variants and Frequency of Acute Symptoms: Analysis of a Multi-institutional Prospective Cohort Study—December 20, 2020—June 20, 2022
Author:
Wang Ralph C1ORCID, Gottlieb Michael2ORCID, Montoy Juan Carlos C1, Rodriguez Robert M1, Yu Huihui3, Spatz Erica S3, Chandler Christopher W4, Elmore Joann G45, Hannikainen Paavali A6, Chang Anna Marie6, Hill Mandy7ORCID, Huebinger Ryan M7, Idris Ahamed H8, Koo Katherine9, Li Shu-Xia3, McDonald Samuel8, Nichol Graham10, O’Laughlin Kelli N11, Plumb Ian D12, Santangelo Michelle13, Saydah Sharon12, Stephens Kari A14, Venkatesh Arjun K315ORCID, Weinstein Robert A9, Weinstein Robert A, Gottlieb Michael, Santangelo Michelle, Koo Katherine, Derden Antonia, Gottlieb Michael, Gatling Kristyn, Guzman Diego, Yang Geoffrey, Kaadan Marshall, Hassaballa Minna, Jerger Ryan, Ahmed Zohaib, Choi Michael, Venkatesh Arjun, Spatz Erica, Lin Zhenqiu, Li Shu-Xia, Yu Huihui, Liu Mengni, Venkatesh Arjun, Spatz Erica, Ulrich Andrew, Kinsman Jeremiah, Dorney Jocelyn, Pierce Senyte, Puente Xavier, Nichol Graham, Stephens Kari, Anderson Jill, Morse Dana, Adams Karen, Maat Zenoura, Stober Tracy, O’Laughlin Kelli N, Gentile Nikki, Geyer Rachel E, Willis Michael, Ruiz Luis, Malone Kerry, Park Jasmine, Rising Kristin, Kean Efrat, Kelly Morgan, Schaeffer Kevin, Hannikainen Paavali, Shughart Lindsey, Shughart Hailey, Renzi Nicole, Amadio Grace, Grau Dylan, Watts Phillip, Cheng David, Miao Jessica, Shutty Carly, Charlton Alex, Hill Mandy, Site Ryan Huebinger, Chavez Summer, Kane Arun, Nikonowicz Peter, Idris Ahamed H, McDonald Samuel, Gallegos David, Martin Riley, Elmore Joann, Wisk Lauren, L’Hommedieu Michelle, Chandler Chris, Eguchi Megan, Roldan Kate Diaz, Villegas Nicole, Moreno Raul, Rodriguez Robert, Wang Ralph C, Montoy Juan Carlos, Kemball Robin, Chan Virginia, Chavez Cecilia Lara, Wong Angela, Arreguin Mireya, Plumb Ian D, Hall Aron J, Saydah Sharon, Briggs-Hagen Melissa,
Affiliation:
1. Department of Emergency Medicine, University of California San Francisco , San Francisco, California , USA 2. Department of Emergency Medicine, Rush University Medical Center , Chicago, Illinois , USA 3. Center for Outcomes Research and Evaluation, Section of Cardiovascular Medicine, Yale School of Medicine , New Haven, Connecticut , USA 4. Division of General Internal Medicine and Health Services Research, David Geffen School of Medicine, University of California Los Angeles , Los Angeles, California , USA 5. Department of Health Policy and Management, Fielding School of Public Health, University of California Los Angeles , Los Angeles, California , USA 6. Sidney Kimmel Medical College, Thomas Jefferson University , Philadelphia, Pennsylvania , USA 7. Department of Emergency Medicine, UTHealth Houston , Houston, Texas , USA 8. Department of Emergency Medicine, University of Texas Southwestern Medical Center , Dallas, Texas , USA 9. Department of Medicine, Division of Infectious Diseases, Rush University Medical Center , Chicago, Illinois , USA 10. Departments of Medicine and Emergency Medicine, University of Washington , Seattle, Washington , USA 11. Departments of Emergency Medicine and Global Health, University of Washington , Seattle, Washington , USA 12. Centers for Disease Control and Prevention, National Center for Immunizations and Respiratory Diseases , Atlanta, Georgia , USA 13. Division of Infectious Diseases, Department of Medicine, Rush University Medical Center , Chicago, Illinois , USA 14. Departments of Family Medicine and Biomedical Informatics & Medical Education, University of Washington , Seattle, Washington , USA 15. Department of Emergency Medicine, Yale School of Medicine , New Haven, Connecticut , USA
Abstract
Abstract
Background
While prior work examining severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern focused on hospitalization and death, less is known about differences in clinical presentation. We compared the prevalence of acute symptoms across pre-Delta, Delta, and Omicron.
Methods
We conducted an analysis of the Innovative Support for Patients with SARS-CoV-2 Infections Registry (INSPIRE), a cohort study enrolling symptomatic SARS-CoV-2-positive participants. We determined the association between the pre-Delta, Delta, and Omicron time periods and the prevalence of 21 coronavirus disease 2019 (COVID-19) acute symptoms.
Results
We enrolled 4113 participants from December 2020 to June 2022. Pre-Delta vs Delta vs Omicron participants had increasing sore throat (40.9%, 54.6%, 70.6%; P < .001), cough (50.9%, 63.3%, 66.7%; P < .001), and runny noses (48.9%, 71.3%, 72.9%; P < .001). We observed reductions during Omicron in chest pain (31.1%, 24.2%, 20.9%; P < .001), shortness of breath (42.7%, 29.5%, 27.5%; P < .001), loss of taste (47.1%, 61.8%, 19.2%; P < .001), and loss of smell (47.5%, 55.6%, 20.0%; P < .001). After adjustment, those infected during Omicron had significantly higher odds of sore throat vs pre-Delta (odds ratio [OR], 2.76; 95% CI, 2.26–3.35) and Delta (OR, 1.96; 95% CI, 1.69–2.28).
Conclusions
Participants infected during Omicron were more likely to report symptoms of common respiratory viruses, such as sore throat, and less likely to report loss of smell and taste.
Trial registration
NCT04610515.
Funder
Centers for Disease Control and Prevention National Center of Immunization and Respiratory Diseases
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Oncology
Cited by
3 articles.
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