Clinical Impact of Noninvasive Plasma Microbial Cell-Free Deoxyribonucleic Acid Sequencing for the Diagnosis and Management of <i>Pneumocystis jirovecii</i> Pneumonia: A Single-Center Retrospective Study-Reference-Cited by-同舟云学术

Clinical Impact of Noninvasive Plasma Microbial Cell-Free Deoxyribonucleic Acid Sequencing for the Diagnosis and Management of Pneumocystis jirovecii Pneumonia: A Single-Center Retrospective Study

Published:2022-12-01 Issue:12 Volume:9 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Foong Kap Sum¹²^ORCID,Mabayoje Mojolaoluwa³,AlMajali Abeer²³⁴

Affiliation:

1. Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center , Boston, Massachusetts , USA

2. Section of Infectious Diseases, University of Illinois College of Medicine , Peoria, Illinois , USA

3. Department of Medicine, University of Illinois College of Medicine , Peoria, Illinois , USA

4. OSF St. Francis Medical Center , Peoria, Illinois , USA

Abstract

Abstract We present 23 cases of Pneumocystis jirovecii pneumonia (PCP) diagnosed with commercially available noninvasive plasma microbial cell-free deoxyribonucleic acid (mcfDNA) assay. Our findings suggest that plasma mcfDNA testing resulted in positive clinical impact for the diagnosis and treatment of PCP and coinfections in 82.6% of cases.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofac652/47513445/ofac652.pdf

Reference26 articles.

1. AIDS-defining opportunistic illnesses in US patients, 1994–2007: a cohort study;Buchacz;AIDS,2010

2. Is it safe to discontinue primary Pneumocystis jiroveci pneumonia prophylaxis in patients with virologically suppressed HIV infection and a CD4 cell count < 200 cells/microL?;Mocroft;Clin Infect Dis,2010

3. Incidence of AIDS-defining opportunistic infections in a multicohort analysis of HIV-infected persons in the United States and Canada, 2000–2010;Buchacz;J Infect Dis,2016

4. Evolving epidemiology of Pneumocystis pneumonia: findings from a longitudinal population-based study and a retrospective multi-center study in Germany;Kolbrink;Lancet Reg Health Eur,2022

5. Current epidemiology of;Morris;Emerg Infect Dis,2004

Cited by 4 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Pneumocystis jirovecii in solid organ transplant recipients: updates in epidemiology, diagnosis, treatment, and prevention;Current Opinion in Infectious Diseases;2024-01-18

2. Prevention, Diagnosis and Management of Pneumocystis jirovecii Infection in Children With Cancer or Receiving Hematopoietic Cell Therapy;Pediatric Infectious Disease Journal;2023-09-21

3. Current Concepts in the Diagnosis and Management of Pneumocystis Pneumonia in Solid Organ Transplantation;Infectious Disease Clinics of North America;2023-09

4. Deciphering the potential of plasma cell-free metagenomic next-generation sequencing using the Karius test;Current Opinion in Infectious Diseases;2023-07-25