Dominant Negative TRAF3 Variant With Recurrent <i>Mycobacterium abscessus</i> Infection and Bronchiectasis-Reference-Cited by-同舟云学术

Dominant Negative TRAF3 Variant With Recurrent Mycobacterium abscessus Infection and Bronchiectasis

Published:2022-08-01 Issue:8 Volume:9 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Liew Mei Fong¹²³,Lim Hui Fang²³,Liang Mui Cheng⁴,Lim Ives⁵⁶,Tan Zhaohong⁷,Tan Rachel Ying Min⁷,Sam Qi Hui⁷⁸,Soe Win Mar⁷,Tay Sen Hee³⁹^ORCID,Xu Shengli⁴¹⁰,Chang Matthew Wook⁸,Foo Roger³⁶^ORCID,Soong Tuck Wah⁴^ORCID,Ravikumar Sharada⁷,Chai Louis Yi Ann³⁷⁸^ORCID

Affiliation:

1. FAST and Chronic Programmes, Alexandra Hospital, National University Health System , Singapore , Singapore

2. Division of Respiratory and Critical Care Medicine, Department of Medicine, National University Hospital, National University Health System , Singapore , Singapore

3. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore , Singapore , Singapore

4. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore , Singapore , Singapore

5. Bioinformatics Institute, Agency for Science, Technology and Research (A*STAR) , Singapore , Singapore

6. Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR) , Singapore , Singapore

7. Division of Infectious Diseases, Department of Medicine, National University Health System , Singapore , Singapore

8. Synthetic Biology for Clinical and Technological Innovation (SynCTI), National University of Singapore , Singapore , Singapore

9. Division of Rheumatology, Department of Medicine, National University Health System , Singapore , Singapore

10. Singapore Immunology Network, Agency for Science, Technology and Research (A*Star) , Singapore , Singapore

Abstract

Abstract Host factors leading to pulmonary nontuberculous mycobacteria (PNTM) disease are poorly understood compared with disseminated NTM disease, which is linked to the interleukin 12–interferon gamma signaling pathway. We investigated the tumor necrosis factor receptor associated factor 3 (TRAF3) R338W variant in a patient with recurrent PNTM infection, demonstrating TRAF3- and TNF-α-deficient phenotypes via ex vivo immune and cloning-transfection cellular studies.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofac379/45228959/ofac379.pdf

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