Seroepidemiology of the Seasonal Human Coronaviruses NL63, 229E, OC43 and HKU1 in France
Author:
De Thoisy Alix1, Woudenberg Tom1, Pelleau Stéphane1, Donnadieu Françoise1, Garcia Laura1, Pinaud Laurie2, Tondeur Laura2, Meola Annalisa3, Arowas Laurence4, Clement Nathalie5, Backovic Marija3, Ungeheuer Marie-Noëlle4, Fontanet Arnaud26, White Michael1, Woudenberg Tom, Pelleau Stéphane, Pinaud Laurie, Tondeur Laura, Ungeheuer Marie-Noëlle, Fontanet Arnaud, White Michael, Pellerin Sandrine Fernandes, Guiheneuf Raphaël, Delamare Catherine, Marlet Karl Stefic and Julien, Brochot Etienne, Castelain Sandrine, Augereau Olivier, Sibilia Jean, Dubos François, Guen Christéle Gras-Le, Coste-Burel Marianne, Imbert-Marcille Berthe-Marie, Schweitzer Cyril, Gatin Amélie, Joulié Aline, Haas Hervé, Cantais Aymeric, Bertholon Frederique, Chinazzo-Vigouroux Marie-France, Duru Cécile, Koffi Aymar Davy,
Affiliation:
1. Infectious Disease Epidemiology and Analytics G5 Unit, Department of Global Health, Institut Pasteur, Université Paris Cité , Paris , France 2. Epidemiology of Emerging Diseases Unit, Department of Global Health, Institut Pasteur, Université Paris Cité , Paris , France 3. Structural Virology Unit, Department of Virology and CNRS UMR 3569, Institut Pasteur, Université Paris Cité , Paris , France 4. Investigation Clinique et Accès aux Ressources Biologiques (ICAReB), Center for Translational Research, Institut Pasteur , Paris , France 5. Coordination Clinique du CRT, Center for Translational Research, Institut Pasteur , Paris , France 6. PACRI Unit, Conservatoire National des Arts et Métiers , Paris , France
Abstract
Abstract
Background
The seasonal human coronaviruses (HCoV) NL63, 229E, OC43, and HKU1 are globally endemic, yet the majority of HCoV infections remain undiagnosed.
Methods
In a cross-sectional study, 2389 serum samples were collected from children and adults in France in 2020. In a longitudinal cohort study, 2520 samples were collected from 898 French individuals followed up between 2020 and 2021. Antibodies to HCoVs were measured using a bead-based multiplex assay.
Results
The rate of waning of anti-HCoV spike immunoglobulin G antibodies was estimated as 0.22–0.47 year−1 for children, and 0.13–0.27 year−1 for adults. Seroreversion was estimated as 0.31–1.37 year−1 in children and 0.19–0.72 year−1 in adults. The estimated seroconversion rate in children was consistent with 20%–39% of children being infected every year with each HCoV.
Conclusions
The high force of infection in children indicates that HCoVs may be responsible for a substantial proportion of fever episodes experienced by children.
Funder
Fondation pour la Recherche Médicale European Research Council Alliance Tous Unis Contre le Virus, Institut Pasteur Fondation de France
Publisher
Oxford University Press (OUP)
Subject
Infectious Diseases,Oncology
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