Reflex Human Immunodeficiency Virus (HIV) Type 1 RNA Testing Enables Timely Differentiation of False-Positive Results From Acute HIV Infection-Reference-Cited by-同舟云学术

Reflex Human Immunodeficiency Virus (HIV) Type 1 RNA Testing Enables Timely Differentiation of False-Positive Results From Acute HIV Infection

Published:2023-12-12 Issue:1 Volume:11 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Kaperak Christopher¹,Eller Dylan²³,Devlin Samantha A²³,Hall André²³,Schmitt Jessica²³,Friedman Eleanor E²³,Beavis Kathleen G⁴,Stanford Kimberly A⁵,Pitrak David²³,McNulty Moira C²³^ORCID

Affiliation:

1. Department of Medicine, University of Chicago Medicine , Chicago, Illinois , USA

2. Section of Infectious Diseases and Global Health, University of Chicago , Chicago, Illinois , USA

3. Chicago Center for HIV Elimination, University of Chicago , Chicago, Illinois , USA

4. Department of Pathology, University of Chicago , Chicago, Illinois , USA

5. Section of Emergency Medicine, University of Chicago , Chicago, Illinois , USA

Abstract

Abstract Accurate, timely human immunodeficiency virus (HIV) diagnosis is critical. Routine HIV screening program data were examined before and after reflex HIV type 1 RNA testing. Reflex testing facilitated confirmation of reactive HIV screening assays (as true or false positives) (odds ratio, 23.7 [95% confidence interval, 6.7–83.4]; P < .0001), improving detection of acute HIV and reducing unconfirmed discordant results.

Funder

Chicago Department of Public Health

Gilead’s Frontlines of Communities in the United States

HIV

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

Link

https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofad629/54345815/ofad629.pdf

Reference27 articles.

1. Laboratory diagnosis of HIV in adults: a review of current methods;Cornett;Clin Infect Dis,2013