Reactivation of Multidrug-Resistant HSV-1 in a Post–Allogenic Hematopoietic Stem Cell Transplant Patient: Dynamic Detection of the Rare A605V Mutation by Next-Generation Sequencing-Reference-Cited by-同舟云学术

Reactivation of Multidrug-Resistant HSV-1 in a Post–Allogenic Hematopoietic Stem Cell Transplant Patient: Dynamic Detection of the Rare A605V Mutation by Next-Generation Sequencing

Published:2024-04-26 Issue:5 Volume:11 Page:
ISSN:2328-8957
Container-title:Open Forum Infectious Diseases
language:en
Short-container-title:

Author:

Zheng Shuxuan¹^ORCID,Rümke Lidewij W¹,Tello Rubio Bruno¹,Rogers Malbert R C¹,van Sluis Geerte L²,Kuball Jürgen H E²,Riezebos-Brilman Annelies¹,Lebbink Robert Jan¹,Verduyn Lunel Frans M¹^ORCID

Affiliation:

1. Department of Medical Microbiology, UMC Utrecht , Utrecht , The Netherlands

2. Department of Haematology UMC Utrecht , Utrecht , The Netherlands

Abstract

Abstract We present an immunocompromised patient with a multiresistant herpes simplex virus–1 reactivation with a rare mutation (A605V) in the viral DNA polymerase gene. Next-generation sequencing suggests the presence of multiple drug-resistant strains before treatment and altered ratios during treatment, affecting the clinical response to aciclovir and foscarnet.

Publisher

Oxford University Press (OUP)

Link

https://academic.oup.com/ofid/advance-article-pdf/doi/10.1093/ofid/ofae250/57399641/ofae250.pdf

Reference14 articles.

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1. Correction to: Reactivation of Multidrug-Resistant HSV-1 in a Post–Allogenic Hematopoietic Stem Cell Transplant Patient: Dynamic Detection of the Rare A605V Mutation by Next-Generation Sequencing;Open Forum Infectious Diseases;2024-06-28